95753-56-3

Basic information

• Product Name: Fmoc-4-Amino-L-phenylalanine
• Synonyms: FMOC-L-PHE(4-NH2)-OH;FMOC-PHE(4-NH2)-OH;FMOC-P-AMINO-L-PHE-OH;FMOC-P-AMINO-PHENYLALANINE;FMOC-P-AMINO-PHE-OH;FMOC-PHE(P-NH2)-OH;FMOC-S-PHE(4-NH2)-OH;FMOC-L-4-AMINOPHENYLALANINE
• CAS NO: 95753-56-3
• Molecular Formula: C₂₄H₂₂N₂O₄
• Molecular Weight: 402.44
• EINECS: 1806241-263-5
• Product Categories: Phenylalanine [Phe, F];Unusual Amino Acids;Fmoc-Amino acid series
• Mol File: 95753-56-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 671.5 °C at 760 mmHg
• Flash Point: 359.9 °C
• Appearance: /
• Density: 1.316 g/cm³
• Storage Temp.: -15°C
• PKA: 3.63±0.10(Predicted)
• CAS DataBase Reference: Fmoc-4-Amino-L-phenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-4-Amino-L-phenylalanine(95753-56-3)
• EPA Substance Registry System: Fmoc-4-Amino-L-phenylalanine(95753-56-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 95753-56-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C24H22N2O4/c25-16-11-9-15(10-12-16)13-22(23(27)28)26-24(29)30-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14,25H2,(H,26,29)(H,27,28)/t22-/m0/s1

Upstream product

• 95753-55-2 N-α-FMOC-4-nitro-L-phenylalanine 
• 949-99-5 4-nitro-3-phenyl-L-alanine 
• 63-91-2 L-phenylalanine 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 943-80-6 4-amino-L-phenylalanine 

Downstream Products

• 197724-51-9 (E)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(phenyldiazenyl)phenyl)propanoic acid 
• 163217-43-4 Fmoc-Phe-(4-N₃)-OH 
• 1443132-14-6 N-(9-fluorenylmethoxycarbonyl)-p-(N-cyclohexylmethylamino)-L-phenylalanine 
• 1552293-09-0 C₂₈H₃₈N₆O₄ 
• 1421639-74-8 C₃₆H₄₆N₈O₅S 
• 1421639-68-0 C₂₇H₃₆N₄O₇S 
• 1421640-06-3 N₃Phe-Leu-Leu-Phe(4-NH₂)EK 
• 1421639-64-6 C₃₂H₄₅N₇O₅S 
• 1421640-00-7 N₃-Phe-Phe(4-NHBoc)-Leu-NHNH₂ 

Relevant articles and documents

Synthesis of new tetrazolyl derivatives of L- and D-phenylalanine

New tetrazolyl derivatives of L- and D-phenylalanine were synthesized by azidation of n-propyl esters of (2S)- and (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(4-aminophenyl)propionic acids and by a series of subsequent chemical transformations. The structure and individuality of the compounds obtained were confirmed by using a complex of spectral and chromatographic methods.

N-alkanoylphenylalanine derivatives

Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

α,α-difluorophosphonomethyl azobenzene derivatives as photoregulated phosphoamino acid analogs. 1. Design and synthesis

A series of novel, photoregulated phosphoamino acid analogs based on an azobenzene core bearing an α,α-difluoromethylphosphonate as a hydrolytically stable phosphate isostere have been prepared with N-Fmoc protection for use in peptide synthesis. Classes of reagents analogous to both phosphotyrosine and phosphoserine/threonine were prepared by a common route employing a nitrosoarene/aniline condensation to form the azo linkage and the Cu(I)-promoted coupling of an iodoarene with (diethylphosphono)difluoromethyl cadmium bromide (Burton's method) to introduce the phosphonate moiety.