- Synthesis of Levobunolol hydrochloride
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Levobunolol hydrochloride (CAS NO.: ), with its systematic name of 1(2H)-lenone, 3,4-dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-, hydrochloride, (-)-, could be produced through many synthetic methods.
Following is one of the synthesis routes: 5-Hydroxy-7-tetralone (I) could react with epichlorohydrin (I) at reflux temperature to afford 5-(3-chloro-2-hydroxypropoxy)-7-tetralone (III), and the yielding compound is then condensed with butylamine (IV) in refluxlng alcohol.
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