Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Cilazaprilat

Related Products

Hot Products

Name

Cilazaprilat

EINECS N/A
CAS No. 90139-06-3 Density 1.34 g/cm3
PSA 110.18000 LogP 1.38370
Solubility N/A Melting Point 150-160 °C
Formula C20H27N3O5 Boiling Point 618.9 °C at 760mmHg
Molecular Weight 389.451 Flash Point 328.1 °C
Transport Information N/A Appearance White to off-white solid
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 90139-06-3 (Cilazaprilat) Hazard Symbols N/A
Synonyms

6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-[(1-carboxy-3-phenylpropyl)amino]octahydro-10-oxo-, [1S-[1a,9a(R*)]]-;Cilazaprilat;Ro 31-3113;

Article Data 1

Cilazaprilat Specification

The IUPAC name of Cilazaprilat is (4S,7S)-7-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid . With the CAS registry number 90139-06-3, it is also named as Cilazaprilate ; Cilazaprilatum ; N-((1S,9S)-1-Carboxy-10-oxoperhydropyridazino-(1,2-alpha)(1,2)diazepin-9-yl)-4-phenyl-L-homoalanine ; Ro 31-3113 ; UNII-WBL76FH528 . It belongs to chiral reagents, intermediates & fine chemicals, metabolites & impurities and pharmaceuticals.

The Cilazaprilat is white to off-white solid. It is the active metabolite of Cilazapril. Cilazaprilat can be used as an ACE inhibitor and antihypertensive. These results were researched by many scientists. They all used experiment to prove that Cilazaprilat is not a scavenger of superoxide anion. Because this agent potentiates endothelium-dependent relaxations to bradykinin, ADP, and aggregating platelets, the present study suggests that, in addition to the lowering of plasmatic levels of angiotensin II, the antihypertensive and cardioprotective effects of cilazaprilat are mediated through an increased production of endothelium-derived relaxing factors. Another experiment prove that cilazaprilat exerts at least a part of its hypotensive effect through decreasing the facilitatory action of endogenous angiotensin II on adrenergic transmission.

The other characteristics of this product can be summarized as: (1)ACD/BCF (pH 5.5): 1 ; (2)ACD/BCF (pH 7.4): 1 ; (3)ACD/KOC (pH 5.5): 1 ; (4)ACD/KOC (pH 7.4): 1 ; (5)#H bond acceptors: 8 ; (6)#H bond donors: 3 ; (7)#Freely Rotating Bonds: 7 ; (8)Index of Refraction: 1.624 ; (9)Molar Refractivity: 102.26 cm3 ; (10)Molar Volume: 289.3 cm3 ; (11)Polarizability: 40.54×10-24 cm3 ; (12)Surface Tension: 67.7 dyne/cm ; (13)Enthalpy of Vaporization: 96.45 kJ/mol ; (14)Vapour Pressure: 3.56E-16 mmHg at 25°C. People can use the following data to convert to the molecule structure. SMILES:O=C(O)[C@@H](N[C@@H]2C(=O)N1N(CCC[C@H]1C(=O)O)CCC2)CCc3ccccc3; InChI: InChI=1/C20H27N3O5/c24-18-15(8-4-12-22-13-5-9-17(20(27)28)23(18)22)21-16(19(25)26)11-10-14-6-2-1-3-7-14/h1-3,6-7,15-17,21H,4-5,8-13H2,(H,25,26)(H,27,28)/t15-,16-,17-/m0/s1.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 90139-06-3