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| CAS No.: | 90139-06-3 |
|---|---|
| Name: | Cilazaprilat |
| Article Data: | 1 |
| Molecular Structure: | |
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| Formula: | C20H27N3O5 |
| Molecular Weight: | 389.451 |
| Synonyms: | 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-[(1-carboxy-3-phenylpropyl)amino]octahydro-10-oxo-, [1S-[1a,9a(R*)]]-;Cilazaprilat;Ro 31-3113; |
| Density: | 1.34 g/cm3 |
| Melting Point: | 150-160 °C |
| Boiling Point: | 618.9 °C at 760mmHg |
| Flash Point: | 328.1 °C |
| Appearance: | White to off-white solid |
| PSA: | 110.18000 |
| LogP: | 1.38370 |
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- Total:6 Page 1 of 1 1
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Specification
The IUPAC name of Cilazaprilat is (4S,7S)-7-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid . With the CAS registry number 90139-06-3, it is also named as Cilazaprilate ; Cilazaprilatum ; N-((1S,9S)-1-Carboxy-10-oxoperhydropyridazino-(1,2-alpha)(1,2)diazepin-9-yl)-4-phenyl-L-homoalanine ; Ro 31-3113 ; UNII-WBL76FH528 . It belongs to chiral reagents, intermediates & fine chemicals, metabolites & impurities and pharmaceuticals.
The Cilazaprilat is white to off-white solid. It is the active metabolite of Cilazapril. Cilazaprilat can be used as an ACE inhibitor and antihypertensive. These results were researched by many scientists. They all used experiment to prove that Cilazaprilat is not a scavenger of superoxide anion. Because this agent potentiates endothelium-dependent relaxations to bradykinin, ADP, and aggregating platelets, the present study suggests that, in addition to the lowering of plasmatic levels of angiotensin II, the antihypertensive and cardioprotective effects of cilazaprilat are mediated through an increased production of endothelium-derived relaxing factors. Another experiment prove that cilazaprilat exerts at least a part of its hypotensive effect through decreasing the facilitatory action of endogenous angiotensin II on adrenergic transmission.
The other characteristics of this product can be summarized as: (1)ACD/BCF (pH 5.5): 1 ; (2)ACD/BCF (pH 7.4): 1 ; (3)ACD/KOC (pH 5.5): 1 ; (4)ACD/KOC (pH 7.4): 1 ; (5)#H bond acceptors: 8 ; (6)#H bond donors: 3 ; (7)#Freely Rotating Bonds: 7 ; (8)Index of Refraction: 1.624 ; (9)Molar Refractivity: 102.26 cm3 ; (10)Molar Volume: 289.3 cm3 ; (11)Polarizability: 40.54×10-24 cm3 ; (12)Surface Tension: 67.7 dyne/cm ; (13)Enthalpy of Vaporization: 96.45 kJ/mol ; (14)Vapour Pressure: 3.56E-16 mmHg at 25°C. People can use the following data to convert to the molecule structure. SMILES:O=C(O)[C@@H](N[C@@H]2C(=O)N1N(CCC[C@H]1C(=O)O)CCC2)CCc3ccccc3; InChI: InChI=1/C20H27N3O5/c24-18-15(8-4-12-22-13-5-9-17(20(27)28)23(18)22)21-16(19(25)26)11-10-14-6-2-1-3-7-14/h1-3,6-7,15-17,21H,4-5,8-13H2,(H,25,26)(H,27,28)/t15-,16-,17-/m0/s1.