Related Products
- 25708-85-4N,N’-diethyloctane-1,10-diamine
- 2570-96-9Octanenitrile,2-methyl-
- 25710-20-72,3-Pyridinediamine,5-chloro-
- 25710-21-8Pyrido[2,3-b]pyrazine-2,3-dione, 7-chloro-1,4-dihydro-
- 25710-23-0Pyrimidine, 4-chloro-5-nitro-6-(1-piperidinyl)-
- 25711-30-21H-Pyrazole-4-carboxaldehyde, 1,5-dimethyl-
- 25711-72-2Urea,N-(3-aminophenyl)-
- 2571-22-4Spiro[2,5-methano-7H-oxireno[3,4]cyclopent[1,2-d]oxepin-7,2'-oxiran]-3(2H)-one,hexahydro-1b,6-dihydroxy-6a-methyl-8-(1-methylethenyl)-,(1aS,1bR,2S,2'R,5R,6S,6aR,7aR,8R)-
- 25712-33-8TRANS-1,2-CYCLOHEXANEDIMETHANOL
- 25712-60-13-Pyrrolidinecarboxylicacid, 1-methyl- (9CI)
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
DIBENZ(b,f)(1,4)OXAZEPINE |
EINECS | N/A |
| CAS No. | 257-07-8 | Density | 1.16g/cm3 |
| PSA | 21.59000 | LogP | 2.97850 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C13H9 N O | Boiling Point | 329.3°Cat760mmHg |
| Molecular Weight | 195.221 | Flash Point | 125°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and inhalation. Experimental teratogenic and reproductive effects. A human skin and eye irritant. Questionable carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
CR; CR(lacrimator); NSC 293779 |
Article Data | 26 |
DIBENZ(b,f)(1,4)OXAZEPINE Synthetic route
- 446-52-6
2-Fluorobenzaldehyde
- 95-55-6
2-amino-phenol
A
- 257-07-8
dibenz[b,f][1,4]oxazepine
B
- 212758-52-6
2-(2-fluorophenyl)benzo[d]oxazole
Conditions
| Conditions | Yield |
|---|---|
| With oxygen; 1,3-diethyl-1H-benzo[d]imidazol-3-ium bromide; sodium hydroxide In o-xylene; para-xylene; m-xylene at 120℃; for 10h; Molecular sieve; Green chemistry; | A 25% B 65% |
Conditions
| Conditions | Yield |
|---|---|
| With poly(ethylene glycol)-400; potassium carbonate at 100℃; for 8h; Product distribution; Further Variations:; Reagents; Solvents; Temperatures; time; | 89% |
| Stage #1: 2-amino-phenol In polyethylene glycol (300) at 50℃; for 0.5h; Stage #2: 2-Fluorobenzaldehyde In polyethylene glycol (300) at 50℃; for 10h; Stage #3: With potassium carbonate In polyethylene glycol (300) at 100℃; for 10h; | 80% |
| With potassium carbonate at 100℃; Sealed tube; | 58% |
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 2-[(2-chlorobenzylidene)amino]phenol With potassium hydroxide In methanol at 20℃; for 0.583333h; Stage #2: In dimethyl sulfoxide at 120℃; for 2h; Further stages.; | 75% |
| Stage #1: 2-[(2-chlorobenzylidene)amino]phenol With potassium hydroxide In methanol at 20℃; for 1h; Stage #2: In dimethyl sulfoxide at 150℃; for 6h; | |
| Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 140 °C / Microwave irradiation 2: N,N-dimethyl-formamide / 140 °C / Microwave irradiation View Scheme |
Conditions
| Conditions | Yield |
|---|---|
| With potassium hydroxide In N,N-dimethyl-formamide at 120℃; for 0.1h; Temperature; Reagent/catalyst; Microwave irradiation; | 87% |
| Stage #1: 2-chloro-benzaldehyde; 2-amino-phenol In 5,5-dimethyl-1,3-cyclohexadiene for 2h; Reflux; Stage #2: In 5,5-dimethyl-1,3-cyclohexadiene at 120℃; for 24h; Stage #3: With sodium In 5,5-dimethyl-1,3-cyclohexadiene for 6h; Reflux; | 75% |
Conditions
| Conditions | Yield |
|---|---|
| With tetrabutylammonium acetate; palladium diacetate; 1,2-diamino-benzene In N,N-dimethyl-formamide at 120℃; Microwave irradiation; | 82% |
Conditions
| Conditions | Yield |
|---|---|
| With polyphosphiric acid; trichlorophosphate at 120 - 130℃; for 2h; Cyclization; | 75% |
- 257-07-8
dibenz[b,f][1,4]oxazepine
Conditions
| Conditions | Yield |
|---|---|
| With polyphosphiric acid; trichlorophosphate at 120 - 130℃; for 2h; Cyclization; | 56% |
Conditions
| Conditions | Yield |
|---|---|
| With potassium carbonate at 100℃; for 5h; | 68% |
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide / 140 °C / Microwave irradiation 2: N,N-dimethyl-formamide / 140 °C / Microwave irradiation 3: N,N-dimethyl-formamide / 140 °C / Microwave irradiation View Scheme | |
| Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide / 140 °C / Microwave irradiation 2: N,N-dimethyl-formamide / 140 °C / Microwave irradiation 3: N,N-dimethyl-formamide / 140 °C / Microwave irradiation View Scheme | |
| Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide / 140 °C / Microwave irradiation 2: N,N-dimethyl-formamide / 140 °C / Microwave irradiation 3: N,N-dimethyl-formamide / 140 °C / Microwave irradiation View Scheme |
A
- 257-07-8
dibenz[b,f][1,4]oxazepine
Conditions
| Conditions | Yield |
|---|---|
| With polyphosphiric acid; trichlorophosphate at 120 - 130℃; for 2h; Cyclization; | A 23% B 31% |
DIBENZ(b,f)(1,4)OXAZEPINE Chemical Properties
Product Name: Dibenz(b,f)(1,4)oxazepine (CAS NO.257-07-8)
Molecular Formula: C13H9NO
Molecular Weight: 195.21666g/mol
Mol File: 257-07-8.mol
Boiling point: 329.3 °C at 760 mmHg
Flash Point: 125 °C
Density: 1.16 g/cm3
Surface Tension: 43.7 dyne/cm
Enthalpy of Vaporization: 54.91 kJ/mol
Vapour Pressure: 0.000342 mmHg at 25°C
XLogP3-AA: 2.6
H-Bond Donor: 0
H-Bond Acceptor: 2
DIBENZ(b,f)(1,4)OXAZEPINE Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LCLo | inhalation | 1500mg/m3/2H (1500mg/m3) | Toxicology. Vol. 8, Pg. 347, 1977. | |
| guinea pig | LD50 | intraperitoneal | 463mg/kg (463mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Toxicology. Vol. 8, Pg. 347, 1977. |
| guinea pig | LD50 | oral | 629mg/kg (629mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: ATAXIA BEHAVIORAL: COMA | Toxicology. Vol. 8, Pg. 347, 1977. |
| hamster | LCLo | inhalation | 1850mg/m3/3H (1850mg/m3) | Toxicology. Vol. 8, Pg. 347, 1977. | |
| mouse | LCLo | inhalation | 1500mg/m3/2H (1500mg/m3) | Toxicology. Vol. 8, Pg. 347, 1977. | |
| mouse | LD50 | intraperitoneal | 242mg/kg (242mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, | |
| mouse | LD50 | intravenous | 37200ug/kg (37.2mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, | |
| mouse | LD50 | oral | 770mg/kg (770mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, | |
| rabbit | LCLo | inhalation | 1500mg/m3/2H (1500mg/m3) | Toxicology. Vol. 8, Pg. 347, 1977. | |
| rabbit | LD50 | intravenous | 26mg/kg (26mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, | |
| rabbit | LD50 | oral | 1760mg/kg (1760mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: COMA BEHAVIORAL: ATAXIA | Toxicology. Vol. 8, Pg. 347, 1977. |
| rabbit | LD50 | skin | > 400mg/kg (400mg/kg) | Toxicology. Vol. 8, Pg. 347, 1977. | |
| rat | LD50 | intraperitoneal | 164mg/kg (164mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, | |
| rat | LD50 | intravenous | 26mg/kg (26mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, | |
| rat | LD50 | oral | 563mg/kg (563mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, |
DIBENZ(b,f)(1,4)OXAZEPINE Consensus Reports
Reported in EPA TSCA Inventory.
DIBENZ(b,f)(1,4)OXAZEPINE Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and inhalation. Experimental teratogenic and reproductive effects. A human skin and eye irritant. Questionable carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.
DIBENZ(b,f)(1,4)OXAZEPINE Specification
Dibenz(b,f)(1,4)oxazepine ,its CAS NO. is 257-07-8,the synonyms is Dibenz(b,f)(1,4)oxazepine ; Dibenzo(b,f)-1,4oxazepine ; Dibenz-1,4-oxazepine ; Ea-3547 .
Post a RFQ
1
What can I do for you?
Get Best Price
Get Best Price for 257-07-8
Dibenz-(b,f)-1,4-oxazephine
