- Diltiazem
- Diltiazem malate
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Cas Database |
| Name |
Diltiazem |
EINECS | 255-796-4 |
| CAS No. | 42399-41-7 | Density | 1.26 g/cm3 |
| PSA | 84.38000 | LogP | 3.43350 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C22H26N2O4S | Boiling Point | 594.4 °C at 760 mmHg |
| Molecular Weight | 414.525 | Flash Point | 313.3 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,(2S-cis)-;(+)-Diltiazem;(+)-cis-Diltiazem;Balcor;Cartia XT;Coras;Dilzem;Dilzem retard;d-Diltiazem;d-cis-Diltiazem; |
Article Data | 19 |
Diltiazem Chemical Properties
IUPAC Name: [(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
Empirical Formula: C22H26N2O4S
Molecular Weight: 414.5178g/mol
EINECS: 255-796-4
Structure of Diltiazem (CAS NO.42399-41-7):
Index of Refraction: 1.62
Molar Refractivity: 115.15 cm3
Molar Volume: 327.6 cm3
Polarizability: 45.65×10-24cm3
Surface Tension: 56.2 dyne/cm
Density: 1.26 g/cm3
Flash Point: 313.3 °C
Enthalpy of Vaporization: 88.6 kJ/mol
Boiling Point: 594.4 °C at 760 mmHg
Vapour Pressure: 4.27E-14 mmHg at 25°C
Classification Code :Antihypertensive agents, Calcium channel blockers, Cardiovascular agents, Drug / Therapeutic Agent, Membrane Transport Modulators, Vasodilator agents
Canonical SMILES: CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC
Isomeric SMILES: CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC
InChI: InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
InChIKey: HSUGRBWQSSZJOP-RTWAWAEBSA-N
Diltiazem Uses
Diltiazem (CAS NO.42399-41-7) is a non-dihydropyridine (DHP) member of the group of drugs known as benzothiazepines, which are a class of calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. It is also an effective preventive medication for migraine. It is a class 3 anti-anginal drug, and a class IV antiarrhythmic. It is a common adulterant of cocaine seized in the UK , despite reducing cocaine cravings in rats (see below). It incites very minimal reflex sympathetic changes.
Diltiazem Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 68mg/kg (68mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE BLOOD: CHANGES IN PLATELET COUNT | Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 273, 1995. |
| mouse | LD50 | intravenous | 61mg/kg (61mg/kg) | Japanese Journal of Toxicology. Vol. 4, Pg. 121, 1991. | |
| mouse | LD50 | oral | 740mg/kg (740mg/kg) | Japanese Journal of Toxicology. Vol. 4, Pg. 121, 1991. | |
| mouse | LDLo | intraperitoneal | 220mg/kg (220mg/kg) | Indian Journal of Experimental Biology. Vol. 34, Pg. 1194, 1996. |
Diltiazem Specification
Diltiazem , its cas register number is 42399-41-7. It also can be called Acalix ; Adizem ; Anoheal ; BRN 3573079 ; CRD-401 ; Cardil ; Cardizem ; Cardizem LA ; Dilacor XR ; Dilcontin ; Dilren ; Dilta-Hexal ; Diltiazem ; Diltiazemum ; Dilticard ; Dilzen ; Endrydil ; HSDB 6528 ; Incoril AP ; UNII-EE92BBP03H ; d-cis-Diltiazem .
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