1. Introduction of Doxazosin mesylate

Doxazosin mesylate is one kind of white crystalline powder. It belongs to the product categories of Active Pharmaceutical Ingredients; Antihypertensive; Intermediates & Fine Chemicals; Pharmaceuticals; Adrenoceptor. What's more, its systematic name is [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2,3-dihydro-1,4-benzodioxin-2-yl)methanone methanesulfonate (1:1). Its classification codes are: (1)Antihypertensive; (2)Drug / Therapeutic Agent; (3)Reproductive Effect. This chemical is an α1a-selective alpha blocker used to treat high blood pressure and urinary retention associated with benign prostatic hyperplasia (BPH).

2. Properties of Doxazosin mesylate

Physical properties of Doxazosin mesylate (1:1) are: (1)ACD/LogP: 0.649; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -0.33; (4)ACD/LogD (pH 7.4): 0.60; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.65; (7)ACD/KOC (pH 5.5): 5.62; (8)ACD/KOC (pH 7.4): 48.37; (9)#H bond acceptors: 10; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 89.49 Å²; (13)Flash Point: 388 °C; (14)Enthalpy of Vaporization: 104.92 kJ/mol; (15)Boiling Point: 718 °C at 760 mmHg; (16)Vapour Pressure: 1.83E-20 mmHg at 25°C.

3. Structure Descriptors of Doxazosin mesylate

You could convert the following datas into the molecular structure:
(1)SMILES: O=S(=O)(O)C.O=C(N3CCN(c2nc1cc(OC)c(OC)cc1c(n2)N)CC3)C4Oc5c(OC4)cccc5
(2)Std. InChI: InChI=1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4)
(3)Std. InChIKey: VJECBOKJABCYMF-UHFFFAOYSA-N

4. Toxicity of Doxazosin mesylate

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 1gm/kg (1000mg/kg)		Drugs in Japan Vol. -, Pg. 712, 1990.
mouse	LD50	intraperitoneal	247mg/kg (247mg/kg)		Drugs in Japan Vol. -, Pg. 712, 1990.
mouse	LD50	oral	2935mg/kg (2935mg/kg)		Drugs in Japan Vol. -, Pg. 712, 1990.
mouse	LD50	subcutaneous	4087mg/kg (4087mg/kg)		Drugs in Japan Vol. -, Pg. 712, 1990.
rat	LD50	intraperitoneal	380mg/kg (380mg/kg)		Drugs in Japan Vol. -, Pg. 712, 1990.
rat	LD50	oral	> 5gm/kg (5000mg/kg)		Drugs in Japan Vol. -, Pg. 712, 1990.
rat	LD50	subcutaneous	> 5gm/kg (5000mg/kg)		Drugs in Japan Vol. -, Pg. 712, 1990.

5. Safety Information of Doxazosin mesylate

When you are using this chemical, please be cautious about it as the following:
This chemcial is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need to wear suitable protective clothing and gloves.