- Emedastine
- Emedastine Difumarate
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| Name |
Emedastine Difumarate |
EINECS | 805-825-7 |
| CAS No. | 87233-62-3 | Density | N/A |
| PSA | 182.73000 | LogP | 1.64120 |
| Solubility | N/A | Melting Point |
148-151° |
| Formula | C17H26N4O•2C4H4O4 | Boiling Point | 446.6 ºC at 760 mmHg |
| Molecular Weight | 534.63 | Flash Point | 223.9 ºC°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | A poison by ingestion and intravenous routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic vapors of NOx. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | A poison by ingestion. |
| Synonyms |
1-(2-Ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate;Emedastinum [INN-Latin];1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-;KB 2413;87233-61-2;Emedastine [INN];1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzoimidazole;1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-, (E)-2-butenedioate (1:2);Daren;1H-Benzimidazole,1-(2-ethoxyethyl)-2- (hexahydro-4-methyl-1H-1,4-diazepin-1- yl)-,(2E)-2-butenedioate (1:2);1-(2-Ethoxyethyl)-2-(4-methylhexahydro-1H-1,4-diazepin-1-yl)benzimidazole fumarate (1:2);Emedastine;Benzimidazole, 1-(2-ethoxyethyl)-2-(4-methylhexahydro-1H-1,4-diazepin-1-yl)-, fumarate (1:2);AL 3432A;Daren (TN);Rapimine;1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzimidazole;LY 188695;Emadine (TN);KB-2413;KG-2413;but-2-enedioic acid; 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzoimidazole;Emedastine difumarate (JAN/USP);Emadine;1-Methyl-4-(1-(2-ethoxyethyl)-1H-benzimidazo)-2-yl)(1,4)diazepane;Emedastine Difumarate [USAN];KG 2413;Emedastina [INN-Spanish];1H-BENZIMIDAZOLE, 1-(2-ETHOXYETHYL)-2-(HEXAHYDRO-4-METHYL-1H-1,4-DIAZEPIN-1-YL)-,(E)-2-BUTENEDIOATE (1:2);BENZIMIDAZOLE,-1-(2-ETHOXYETHYL)-2-(4-METHYLHEXAHYDRO-1H-1,4-DIAZEPIN-1-YL)-, FUMARATE (1:2);1-(2-ETHOXYETHYL)-2-(4-METHYL-1-HOMOPIPERAZINYL)-BENZIMIDAZOLE DIFUMARATE; |
Emedastine Difumarate Specification
Emedastine Difumarate (CAS NO.87233-62-3) is has IUPAC Name of (E)-but-2-enedioic acid;1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole and it is also called 1-(2-Ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate ; 1-(2-Ethoxyethyl)-2-(4-methylhexahydro-1H-1,4-diazepin-1-yl)benzimidazole fumarate (1:2)
1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzimidazole fumarate (1:2) ; 1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-, (E)-2-butenedioate (1:2) ; AL 3432A ; Benzimidazole, 1-(2-ethoxyethyl)-2-(4-methylhexahydro-1H-1,4-diazepin-1-yl)-, fumarate (1:2) ; KB-2413 ; LY 188695 ; Rapimine ; UNII-42MB94QOSM ; emadine .
Emedastine Difumarate (CAS NO.87233-62-3) is an antihistamine used in eye drops to treat allergic conjunctivitis. It is one kind of dangerous material, a poison by ingestion and intravenous routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic vapors of NOx. And its toxic tabulation is:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | 193mg/kg (193mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 209, 1990. |
| guinea pig | LD50 | oral | 744mg/kg (744mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 801, 1984. | |
| mouse | LD50 | intravenous | 93mg/kg (93mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 209, 1990. |
| mouse | LD50 | oral | 628mg/kg (628mg/kg) | United States Patent Document. Vol. #4430343, | |
| mouse | LD50 | subcutaneous | 609mg/kg (609mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 209, 1990. |
| rat | LD50 | intravenous | 72mg/kg (72mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 209, 1990. |
| rat | LD50 | oral | 1854mg/kg (1854mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 209, 1990. |
| rat | LD50 | subcutaneous | 643mg/kg (643mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 39, Pg. 209, 1990. |
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