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J. Cudaj, J. Podlech
LETTER
3,4¢,5¢-Trihydroxy-5-methoxy-2¢-methyl-biphenyl-2-carboxylic
Acid [Altenusin (6)]
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Pd/C (10%, 18.0 mg, 171 mmol) was added to a solution of protected
alterlactone 17 (20.0 mg, 43.0 mol) in EtOAc (1 mL). The atmo-
sphere was replaced with H2, and the mixture was stirred for 8 h at
r.t. (monitoring with TLC). The mixture was filtered, and the filtrate
was concentrated to yield altenusin (6) as a colorless solid (11.9 g,
1
43.0 mmol, quant.). Rf = 0.13 (CH2Cl2–MeOH = 10:1). H NMR
(250 MHz, CD3OD): d = 1.92 (s, 3 H, CH3), 3.81 (s, 3 H, OMe),
6.17 (d, 4J = 2.6 Hz, 1 H, ArH), 6.43 (d, 4J = 2.6 Hz, 1 H, ArH), 6.49
(s, 1 H, ArH), 6.59 (s, 1 H, s, ArH) ppm. The analytical data are in
full accordance with published data.9b,15b
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Supporting Information for this article is available online at
experimental and spectroscopic data for all compounds, and spectra
of title compounds.
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Acknowledgment
J.C. is grateful for a grant of the Karlsruhe House of Young Scien-
tists (KHYS), which allowed for a stay abroad.
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Synlett 2012, 23, 371–374
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