Journal of Medicinal Chemistry p. 285 - 289 (1980)
Update date:2022-08-04
Topics:
Kreighbaum
Matier
Dennis
Minielli
Deitchman
Perhach Jr.
Comer
A series of 25 aryloxypropanolamines containing the 3-indolyl-tert-butyl[i.e., 1,1-dimethyl-2-(1H-indol-3-yl)ethyl] or substituted 3-indolyl-tert-butyl moiety as the N substituent is reported. These compounds have been tested for antihypertensive activity in spontaneously hypertensive rats (SHR), β-adrenergic receptor antagonist action in conscious normotensive rats, vasodilating activity in ganglion-blocked rats with blood pressure maintained by angiotensin II infusion, and for intrinsic sympathomimetic action (ISA) in reserpinized rats. Some of the compounds exhibit antihypertensive activity in combination with β-adrenergic receptor antagonist and vasodilating action. The structure-activity relationships in these tests are discussed.
View MoreJiangxi Dongxu Chemical Science & Technology Co.,Ltd
Contact:+86-791-86899381
Address:Nanchang, Jiangxi, China
Shanghai Boyners Pharmaceutical co., LTD.
Contact:+86-02131329586/02154581719
Address:No.328,1#315,Wuhe Road, Shanghai, ,shanghai,China (Mainland)
HEZE KINGVOLT CHEMICAL CO., LTD
Contact:86-573-82118911
Address:Juancheng Industry Park
Shanghai Yuking Water Soluble Material Tech Co., Ltd
Contact:86-21-68286299
Address:4F, 13B, No. 600, South Xinyuan Road 201306, Shanghai, China
ShangHai Soyoung Biotechnology Inc
website:http://www.soyoungbio.com
Contact:+86-21-69893009
Address:shanghai
Doi:10.1002/chem.201304240
(2014)Doi:10.1016/S0031-9422(00)88465-4
(1972)Doi:10.1002/ddr.21726
(2020)Doi:10.1248/cpb.56.423
(2008)Doi:10.1021/jo801017b
(2008)Doi:10.1016/0022-328X(96)06218-3
(1996)