Synthetic Communications p. 3840 - 3853 (2008)
Update date:2022-08-03
Topics:
Choy, Jason
Jaime-Figueroa, Saul
Jiang, Laurence
Wagner, Paul
The thermolytic deprotection of N-Boc compounds was accomplished using TFE (2,2,2-trifluoroethanol) or HFIP (hexafluoroisopropanol) as solvents. Even though the cleavage of the t-butylcarbamate (Boc) group can be achieved at solvent reflux temperature, the deprotection process was significantly accelerated under microwave-assisted conditions. The practicality of this methodology was demonstrated on alkyl, aryl, and heteroaromatic N-Boc-amines. Copyright Taylor & Francis Group, LLC.
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