Tetrahedron p. 5309 - 5328 (1991)
Update date:2022-08-03
Topics:
Baldwin, Jack E.
Bradley, Mark
Abbott, Shaun D.
Adlington, Robert M.
The three tripeptides δ-L-α-aminoadipoyl-L-cysteinyl-D-propargylglycine, δ-L-α-aminoadipoyl-L-cysteinyl-D-cyanoalanine and δ-L-α-aminoadipoyl-L-cysteinyl-D-<4,4,5,5-2H4>-norvaline were synthesised and incubated with the enzyme Isopenicillin N Synthase (IPNS).All incubation mixtures contained biologically active products, and led to the isolation of four new penicillins (β-ethyl, α-acetylenic, α- and β-nitrile) following purification by reverse phase HPLC.The stereochemistries of formation of monosubstituted penicillins with IPNS are rationalised.
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(2008)Doi:10.1007/BF00902635
(1956)Doi:10.1021/jm00127a025
(1989)Doi:10.1139/v87-014
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