Nucleosides, nucleotides and nucleic acids p. 353 - 359 (2011)
Update date:2022-08-04
Topics:
Xu, Shaohong
Yao, Peng
Chen, Gairong
Wang, Hui
A new efficient route for the synthesis of 2-chloro-2';-deoxyadenosine (Cladribine), CdA) has been developed. The key step of this method was selective deprotection of the acetyl group at the 2' position; the 3', 5' acetyl groups were not affected. This can be accomplished efficiently with hydroxylamine hydrochloride and sodium acetate in pyridine. The 2' hydroxyl group was removed by the Barton-McCombie reaction. Using this strategy, CdA was prepared in five steps and 31.0% yields. Copyright Taylor and Francis Group, LLC.
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Doi:10.1002/jhet.648
(2011)Doi:10.1021/jm301654b
(2013)Doi:10.1007/BF00807429
(1995)Doi:10.1016/S0040-4020(01)89051-7
(1990)Doi:10.1039/c0ob00308e
(2010)Doi:10.1002/anie.201600400
(2016)