Synthetic Communications p. 1796 - 1801 (2013)
Update date:2022-08-02
Topics:
Rasheed, Mohammed Abdul
Shaik, Nagul Meera
Nirogi, Ramakrishna
A concise and simple synthesis of M1 allosteric agonist 1-(1′-(2-methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d] imidazol-2(3H)-one (TBPB) using economical and commercially available orthophenylenediamine (O-PDA) and Boc piperidone has been described. The disclosed scheme allows synthesizing more analogs that were otherwise difficult to prepare with the original method. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.
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Doi:10.1016/j.tetasy.2013.01.019
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