Tetrahedron p. 6875 - 6880 (1994)
Update date:2022-08-03
Topics: Asymmetric synthesis Base Catalyst Asymmetric addition Ketoprofen Pantolactone Methyl (3-benzoylphenyl) ketene
Calmes, Monique
Daunis, Jacques
Jacquier, Robert
Natt, Francois
The best diastereoselectivity of addition of a chiral alcohol to the ketene derived from ketoprofen was obtained with R or S pantolactone (ed=99percent).Depending on the tertiary amine used both for ketene formation and as catalyst during addition, the diastereoisomeric ratio of esters could be strongly modified and even inverted.Mild saponification afforded R or S ketoprofen in enantiomeric excess of up to 99percent.
View MoreNingBO Hong Xiang Biochem.Co.Ltd
website:http://www.hxbiochem.com
Contact:0574-66003444
Address:Ning Bo Bei Lun
Hangzhou Dingyan Chem Co., Ltd
website:http://www.dingyanchem.com
Contact:86-571-87157530-8001
Address:RM.1118,NO.1 Building, Baiyun Tower,Jianggan Area, Hangzhou city, China,310004
Feiyang Biotechnology Co., Ltd.
Contact:+86-533-7866339
Address:Qilu Chemistry Park, 200m north of Management Community Building of Park
Contact:+86-731-84427351
Address:154 JIANXIANG SOUTH ROAD
Xuzhou Tianrun Chemical Co.,Ltd
website:http://www.tianrunchem.cn
Contact:86-516-83832636
Address:fuxing road
Doi:10.1016/S0040-4039(00)73323-5
(1994)Doi:10.1021/ja00500a021
(1979)Doi:10.1039/c3gc42124d
(2014)Doi:10.1039/d0ob01582b
(2020)Doi:10.1021/ic50035a007
(1966)Doi:10.1021/jo500148j
(2014)