Journal of Organic Chemistry p. 4402 - 4412 (2019)
Update date:2022-07-29
Topics:
Li, Xing
Feng, Tao
Li, Dongjun
Chang, Honghong
Gao, Wenchao
Wei, Wenlong
A direct, highly efficient KOAc-catalyzed one-pot three-component approach for the preparation of various functionalized isoxazolidines via the 1,3-dipolar cycloaddition reactions of readily accessible diazo compounds, nitrosoarenes, and alkenes has been reported. The cheap and readily available catalyst and starting materials, excellent functional group compatibility, wide substrate scope, high yields, and excellent chemo-, regio-, and diastereoselectivities make this protocol an attractive alternative.
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