Biomacromolecules p. 1272 - 1279 (2016)
Update date:2022-08-03
Topics:
Codera, Victoria
Edgar, Kevin J.
Faijes, Magda
Planas, Antoni
Control of the monomer sequence in polymers is extraordinarily difficult by chemical synthesis, though Nature routinely exerts such control, including in the biosynthesis of polysaccharides. This inability has prevented us from being able to match the exquisite structure-activity control exhibited in biosynthesis of bioactive natural polysaccharides. We here address a powerful approach, whereby enzyme-catalyzed polymerization of properly modified building blocks is introduced as a simple route affording polysaccharides with controlled sequence and functionalization pattern. Targeting cellulose as a versatile scaffold for novel biomaterials, we describe the preparation of a perfectly alternating polysaccharide with repeat unit 6′-azido-6′-deoxycellobiose by a glycosynthase-catalyzed polymerization using the Humicola insolens cellulase Cel7B E197A mutant, and its further functionalization to give novel modified cellulose derivatives with a regular substitution pattern.
View MoreHangzhou Mole's Science & Technology Co.,Ltd.
Contact:+86-571-56880228
Address:15F Guodu development Building, NO.182 Zhaohui Road
RongCheng Tianyu Technology Co.,Ltd.
Contact:86-631-7519595
Address:220Ping Donghai Road RongChengCity,ShangDong Province China
Wuhan Fortuna Chemical Co.,Ltd
website:http://www.fortunachem.com
Contact:86-27-59207852
Address:Add: Room 2015, No.2 Building, Kaixin Mansion No.107 Jinqiao Avenue, Wuhan, China
Contact:+86-571-86491666
Address:SHI XIANG ROAD
Compro Shijiazhuang Fine Chemical Co., Ltd
Contact:0086-311-89689838
Address:Economic and Technological Development Zone of Shijiazhuang,Hebei
Doi:10.1039/j39690001901
(1969)Doi:10.1016/S0040-4039(99)00880-1
(1999)Doi:10.1021/jo00830a004
(1970)Doi:10.1021/ja058454p
(2006)Doi:10.1021/ja01083a031
(1965)Doi:10.1016/S0968-0896(99)00039-5
(1999)