Journal of Organic Chemistry p. 7962 - 7969 (2018)
Update date:2022-08-04
Topics: Carboxylic Acids Experimental terms Direct amidation α-Acyl Enol Ester Active Intermediate
Xu, Xianjun
Feng, Huangdi
Huang, Liliang
Liu, Xiaohui
The development of a highly efficient and simple protocol for the direct amidation of carboxylic acids is described employing ynoates as novel coupling reagents. The transformation proceeds in good to excellent yields via in situ α-acyl enol ester intermediates formation under mild reaction conditions. This useful method has been demonstrated for a range of substrates to provide a succinct access to structurally diverse amides, including key intermediates of glibenclamide, tiapride hydrochloride, and nateglinide, and can be conducted on a mole scale.
View MoreShanghai Zhihua ChemTech Co., Ltd.
Contact:+86-13774313779
Address:Room 817 Suite B 3333 Shenjiang Road
Shanghai Yudiao Chemistry Technology Co.,Ltd
Contact:0086-18964703211
Address:Building NO.5, NO.218,Rongtian Road,ganxiang town,Jinshan District,shanghai,201518,china
Chengdu Pukang Biotechnology Co., Ltd
Contact:+86-28-82550498
Address:No. 558 Rulin Road,Xinjin county,Chengdu city, China
NINGBO PANGS CHEM INT’L CO.,LTD.
Contact:+86-574-27666845
Address:FLOOR 21,BUILDING NO.11,XIN TIAN DI,NO.689 SHI JI ROAD,NINGBO CHINA
Nanjing Spring & Autumn Biological Engineering Co., Ltd.
Contact:86-18051083338
Address:Suite# 210, No. 1 BuildingNanjing Agricultural Biotechnology High-tech Entrepreneurship Center, No. 4 Tongwei Road, Xuanwu District, Nanjing,China
Doi:10.1016/0040-4039(94)88150-2
(1994)Doi:10.1016/S0277-5387(99)00331-9
(2000)Doi:10.1002/adsc.202001365
(2021)Doi:10.1016/j.tetlet.2016.10.099
(2016)Doi:10.1248/cpb.37.1044
(1989)Doi:10.1016/S0022-1139(99)00291-2
(2000)