Communications
Nguyen, X. Huang, S. L. Buchwald, J. Am. Chem. Soc. 2003, 125,
structure–activity relationship study suggests the ligand bulk
11818 – 11819.
À
plays an important role in C O bond-forming reactions
À
[9] After this work was completed, the use of 6 for C N bond-
possibly through instilling conformational rigidity in inter-
mediates within the catalytic cycle.
forming reactions with amide nucleophiles was reported: M. C.
Willis, G. N. Brace, I. P. Holmes, Synthesis 2005, 3229 – 3234.
[10] See the Supporting Information for details.
Received: March 31, 2006
Published online: May 30, 2006
À
Keywords: biaryl phosphines · C O bond formation · palladium ·
substituent effects · synthetic methods
.
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