Tetrahedron Letters p. 10085 - 10089 (2000)
Update date:2022-08-03
Topics:
Rueger
Stutz
Goschke
Spindler
Maibaum
We report a convergent synthesis of the potent orally active non-peptide renin inhibitor CGP60536B. The key reaction employs the coupling of the enantiopure Grignard species derived from chloride 13 with the diastereomerically pure γlactone 9b. The stereoselective reduction of the resulting ketone 14b has been thoroughly investigated. (C) 2000 Elsevier Science Ltd.
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