Bioorganic and Medicinal Chemistry Letters p. 3833 - 3838 (2006)
Update date:2022-09-26
Topics:
Rockway, Todd W.
Zhang, Rong
Liu, Dachun
Betebenner, David A.
McDaniel, Keith F.
Pratt, John K.
Beno, David
Montgomery, Debra
Jiang, Wen W.
Masse, Sherie
Kati, Warren M.
Middleton, Tim
Molla, Akhteruzzaman
Maring, Clarence J.
Kempf, Dale J.
A series of non-nucleoside HCV NS5B polymerase inhibitors based on the N-1-benzyl or N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine core substituted in the D-ring aromatic moiety have been prepared and evaluated. Aromatic substituents extending from position 7 of the D-ring exhibited excellent potency against both genotypes 1a and 1b.
View MoreSHANDONG QINGYUNCHANGXIN CHEMICAL SCIENCE-TECH CO.,LTD
Contact:86-21-60560171
Address:1689Donghuan Rade,Qingyun County, Dezhou City, Shandong,China
Tianjin Pharmacn Medical Technology Co.,Ltd.
Contact:86-22-60122566ext.866(English),23359620
Address:Green Industrial Base, 6 Haitaifazhan Sixth Rd., Huayuan Industrial Area, Tianjin, 300384, China
Puyang Willing Chemicals Co.,Ltd.
Contact:86-393-4840366
Address:Puyang Henan China
Suzhou Jingye Medicine & Chemical Co., Ltd
website:http://www.jingyechem.cn
Contact:+86-512-66658588
Address:No. 88, Sanlian Street, Jinfeng Road, Suzhou New District, Jiangsu Province, P. R. China
Binzhou Holly Pharmaceutical Co.,Ltd.
Contact:74517
Address:No.15 Dapu Road,Huangpu District Shanghai,P.R.China
Doi:10.1021/ja027750o
(2002)Doi:10.1002/1522-2675(20010321)84:3<594::AID-HLCA594>3.0.CO;2-9
(2001)Doi:10.1016/S0960-894X(00)00707-1
(2001)Doi:10.1055/s-0035-1562524
(2016)Doi:10.1002/jhet.3419
(2019)Doi:10.1021/jo00130a016
(1995)