Molecules p. 583 - 588 (2006)
Update date:2022-08-05
Topics:
Fustero, Santos
Gonzalez, Javier
Del Pozo, Carlos
1,4-Benzodiazepine N-nitrosoamidines have been used as scaffolds for the preparation of different tricyclic derivatives. Replacement of the N-nitrosoamidine moiety through treatment with the nucleophiles acetylhydrazine, aminoacetaldehyde dimethylacetal and 1-amino-2-propanol, followed by an acid-catalyzed cyclization step, afforded triazolo and imidazobenzodiazepines 1, 6, and 7, respectively, in good yields. When acetylhydrazine is used as a nucleophile, the overall process provides an alternative route to alprazolam (1b) and triazolam (1c), respectively.
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Doi:10.1016/S0040-4020(01)99385-8
(1973)Doi:10.1055/s-1993-35863
(1993)Doi:10.1016/j.molliq.2019.03.126
(2019)Doi:10.1016/S0040-4039(01)02189-X
(2002)Doi:10.1016/j.bmcl.2014.03.015
(2014)Doi:10.1039/c39730000220
(1973)