ChemComm
DOI: 10.1039/C5CC03P42a9gAe 4 of 4
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Feng, H. Liu, X. Yu, Y. Yamamoto and M. Bao, RSC Adv., 2013, 3,
20379.
In summary, an efficient method for one-pot nitrile synthesis
has been developed under mild conditions with affordable and
simple starting materials. In this novel protocol, inexpensive and
widely available acetone functions both as a solvent and a
hydrogen acceptor. The poisoning of palladdium catalyst by the
azido anion (N3¯) was observed in mentioned results. The wide
availability of the starting materials, mild reaction conditions, and
experimental simplicity demonstrate that the present
methodology is highly useful in organic chemistry.
6
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5
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We are grateful to the National Natural Science Foundation of
China (Nos. 21173032 and 21372035) for their financial support.
Notes and references
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State Key Laboratory of Fine Chemicals, Dalian University of
Technology, Dalian 116023, China. Fax: +86-0411-84986180; Tel: +86-
15 0411-84986180; E-mail: mingbao@dlut.edu.cn.
† Electronic Supplementary Information (ESI) available: Experimental
procedures and spectroscopic data for isolated compounds. See
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15 The formation of benzaldehyde was observed in the presence of water.
This observation demonstrating that the palladium benzylideneamide
intermediate A generated in the catalytic cycle.
16 The formation of isopropyl alcohol was determined by GC-MS. See
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