Tetrahedron p. 4694 - 4707 (2013)
Update date:2022-08-03
Topics:
Weinberg, Kamil
Stoit, Axel
Kruse, Chris G.
Haddow, Mairi F.
Gallagher, Timothy
The synthesis and differential substitution/protection of a series of spirodiamine scaffolds are described. Methods for selective access to the two mono-N-methyl isomers based on 2,7-diazaspiro[4.5]decane are also described. Key precursors associated with this chemistry are prone to rearrangement and methods for circumventing this issue are reported. While direct mono-carbamoylation (Boc) was not efficient, selective deprotection of doubly Boc-protected derivatives derived from symmetrical diamines provided mono-Boc variants. N-Arylation, exemplified by a series of monosubstituted spirodiamines incorporating the 2-chloro-5-pyridyl moiety, which is a privileged nicotinic agonist substructure, has also been carried out to provide monoarylated secondary and tertiary spirodiamines variants.
View MoreTIANJIN BAOLIRUITE CHEMICALS CO.,LTD
Contact:+86-022-58652605
Address:NO.60,xiqing high-end metal products industrial zone, Tianjin, China.
website:http://www.sagechem.com
Contact:+86-571-86818502
Address:Room C1301, New Youth Plaza, 8 Jia Shan Road, Hangzhou, China
website:http://www.chinapeptides.com
Contact:+86-021-50792271
Address:Building 24A, 300 Chuantu Road, Chuansha, Pudong new area, Shanghai, China, 201202
Dongguan Albiya Energy Science and Technology Co.,Ltd
Contact:+86-769-22181286
Address:Huanan Industial Park, Dongguan,China
Henan Yellow River New Material Technology Co.Ltd.
website:http://www.yellowriverchem.com
Contact:0086-373-7278760
Address:Chengguan Town, Yuanyang County
Doi:10.1016/S0960-894X(02)00629-7
(2002)Doi:10.1055/s-2007-991075
(2007)Doi:10.1002/jlcr.695
(2003)Doi:10.1080/00304940309355864
(2003)Doi:10.3390/molecules26133991
(2021)Doi:10.1039/JR9650001045
()