Turkish Journal of Chemistry p. 359 - 368 (2019)
Update date:2022-07-29
Topics:
Tian, Bing Ren
Zhang, Rui Xia
Chu, Hui Min
Huang, Qing
Wang, Zhi Zhong
An effective procedure for the synthesis of α-hydroxyphenylacetic acid with cyclodextrin (CD) catalysts was developed. The phase-transfer catalyst types, catalyst loadings, reaction times, reaction temperatures, and substrate molar ratios were investigated to optimize the reaction conditions. In addition, the factors that affect the reaction were studied, and the relationship between benzaldehyde and β-cyclodextrin (β-CD) was analyzed through 2D-ROESY. The equilibrium constant when β-CD was used as the catalyst was calculated. The results indicated that β-CD is the optimal catalyst for the reported reaction (yield: 69.08%). Furthermore, the mechanism underlying the reported reaction was proposed.
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