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ChemComm
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COMMUNICATION
Journal Name
simple and efficient and proceeds under mild and metal-free
conditions via the condensation of the starting aldehyde and
amine, followed by cyclization and concomitant aromatization.
This method is environmentally benign, owing to the fact that it
does not require harmful metals or reagents, and water is the
sole by-product. The current strategy is excellent to incorporate
1, 1010-1015; (j) J. M. Neely and T. RoviDs,OJI:A1m0.1C0h3e9m/C9SCoCc,021009174A,
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pyridine rings onto a wide variety of
, -unsubstituted
aldehydes, including natural products and key intermediates.
The utility and efficiency of this method was demonstrated
through the synthesis of the iridoid natural product, (
actinidine ( ).
−)-
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Conflicts of interest
There are no conflicts to declare.
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