Journal of Organic Chemistry p. 2070 - 2077 (2016)
Update date:2022-08-04
Topics:
Yan, Qiaozhi
Kong, Duanyang
Zhao, Wei
Zi, Guofu
Hou, Guohua
An additive-free enantioselective hydrogenation of β,β-disubstituted unsaturated carboxylic acids catalyzed by the Rh-(R,R)-f-spiroPhos complex has been developed. Under mild conditions, a wide scope of β,β-disubstituted unsaturated carboxylic acids were hydrogenated to the corresponding chiral carboxylic acids with excellent enantioselectivities (up to 99.3% ee). This methodology was also successfully applied to the synthesis of the pharmaceutical molecule indatraline.
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