10.1002/adsc.202000825
Advanced Synthesis & Catalysis
COMMUNICATIONS
Reference
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In summary, an efficient preparation of
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(thiophen-2-yl)pyridines and cyclohexadienone-
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Experimental Section
General Procedure for Rhodium(III)-Catalyzed
Hydroarylation and Relay Thiophene-Promoted
Intramolecular [2+2] Cycloaddition
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(thiophen-2-yl)pyridine
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(0.40 mmol, 2.0 equiv),
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equiv) and toluene (1 mL) under nitrogen atmosphere.
Then the reaction mixture was stirred at 100 C for 8 h.
o
After completion of the reaction, the resulting mixture was
cooled to room temperature, quenched with saturated
aqueous NaHCO3 (2 mL) and extracted with DCM (15 mL
× 3). The combined organic phases were dried over
anhydrous Na2SO4, filtered and concentrated in vacuo. The
residue was purified by silica gel (200−300 mesh) column
chromatography to afford the desired product 3.
Acknowledgements
Financial support was generously provided by the National
Natural Science Foundation of China (Nos. 21871184, 81903423,
and 21871284), the Shanghai Municipal Education Commission
(2019-01-07-00-10-E00072), the Shanghai Sailing Program
(19YF1449300, 20YF1449300), the Program of Shanghai
Academic/Technology Research Leader (20XD1403600), and the
Science and Technology Commission of Shanghai Municipality
(18401933500).
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2013, 15, 882−885; b) P. Lu, T. Bach, Angew. Chem.
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6
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