RSC Advances
Communication
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E. W. Meijer, J. Am. Chem. Soc., 1998, 120, 6761.
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Conclusions
In this communication we have demonstrated a one-pot,
microwave-directed methodology for the synthesis of biologi-
cally active 2-amino-4-pyrimidinones, a class of 2-amino-
pyrimidines. The high-yield reactions were performed in
presence of mild base (K2CO3) without any solvent and were
completed in a very short period of time (10 min). In order to
study potential utilities of the synthesized compounds as arti-
cial nucleobase-pairs, we have isolated co-crystals which show
strong pairing properties with cytosine, as strong as that of
natural G:C base-pair. Such modied nucleobase analogues
could have potential applications for biomolecular recognition,
apart from their pharmaceutical uses.
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Acknowledgements
20 M. S. Digani, S. Bag, R. Bairwa, N. R. Tawari and
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We would like to acknowledge DST-SERB (Grant no. SR/FT/SC-
27/2011), New Delhi, India, for providing the laboratory equip-
ments and nancial assistance. We thank CSIR (New Delhi,
India, grant no. 02(0017)/11/EMR-II) for nancial support. We
also acknowledge CIF, IIT Guwahati, for recording the NMR
spectra.
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˚
˚
ꢀ
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(2). Monoclinic, P21/c. a ¼ 12.4798(6) A, b ¼ 6.8611(5) A, c ¼
ꢀ
ꢀ
˚
17.0339(10) A. a ¼ 90.00 , b ¼ 95.021(5) , g ¼ 90.00 . Unit
cell volume ¼ 1452.94(15) A. Z ¼ 4. m ¼ 0.097 mmꢁ1, r
˚
(calc.) ¼ 1.364 g cmꢁ3, Mo Ka radiation, R1 ¼ 0.0501,
R1,all data ¼ 0.0678, wR (F2) ¼ 0.0856, wR (F2)all data ¼ 0.0935.
Co-crystal data for compound 6:cytosine complex: CCDC #
980516. Formula: C8H13N3O/C4H5N3O$H2O. Temperature (K):
˚
˚
296 (2). Monoclinic, P21/n. a ¼ 15.5249(9) A, b ¼ 5.5769(3) A,
ꢀ
ꢀ
ꢀ
˚
c ¼ 18.7323(11) A. a ¼ 90.00 , b ¼ 112.714(3) , g ¼ 90.00 .
Unit cell volume ¼ 1496.07(15) A. Z ¼ 4. m ¼ 0.098 mmꢁ1, r
˚
(calc.) ¼ 1.316 g cmꢁ3, Mo Ka radiation, R1 ¼ 0.0405,
10 P. S. Shirude, B. Paul, N. R. Choudhury, C. Kedari,
R1,all data ¼ 0.0528, wR (F2) ¼ 0.1109, wR (F2)all data ¼ 0.1209.
B. Bandodkar and B. G. Ugarkar, ACS Med. Chem. Lett., 33 K. Brameld, S. Dasgupta and W. A. Goddard III, J. Phys.
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Chem. B, 1997, 101, 4851.
15090 | RSC Adv., 2014, 4, 15087–15090
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