ACCEPTED MANUSCRIPT
21. Kumar A, Ma H, Zhang X, Huang K, Jin S, Liu J, et al.Gold
Graphic Abstract
nanoparticles functionalized with therapeutic and targeted peptides
for cancer treatment. Biomaterials. 2012;33(4):1180-1189.
22. Wawrzynczak E, Davies A. Strategies in antibody therapy of cancer.
Clin. Exp. Immunol. 1990;82(2):189-193.
23. Arap W, Pasqualini R, Ruoslahti E. Cancer treatment by targeted
drug delivery to tumor vasculature in a mouse model. Science.
1998;279(5349):377-380.
24. Kue CS, Kamkaew A, Burgess K, Kiew LV, Chung LY, Lee HB.
Small molecules for active targeting in cancer. Med. Res. Rev. .
2016;36(3):494-575.
25. Alley SC, Okeley NM, Senter PD. Antibody–drug conjugates:
targeted drug delivery for cancer. Curr. Opin. Chem. Biol.
2010;14(4):529-537.
26. Chen S, Zhao X, Chen J, Chen J, Kuznetsova L, Wong SS, et
al.Mechanism-based tumor-targeting drug delivery system.
Validation of efficient vitamin receptor-mediated endocytosis and
drug release. Bioconjugate Chem. 2010;21(5):979-987.
27. Gupta Y, Kohli DV, Jain SK. Vitamin B 12-mediated transport: a
potential tool for tumor targeting of antineoplastic drugs and
imaging agents. Crit. Rev. Ther. Drug Carrier Syst. . 2008;25(4).
28. Paganelli G, Magnani P, Zito F, Villa E, Sudati F, Lopalco L, et
al.Three-step monoclonal antibody tumor targeting in
carcinoembryonic antigen-positive patients. Cancer research.
1991;51(21):5960-5966.
29. Li K, Qiu L, Liu Q, Lv G, Zhao X, Wang S, et al.Conjugate of biotin
with silicon(IV) phthalocyanine for tumor-targeting photodynamic
therapy. J Photochem Photobiol B. 2017;174:243-250.
30. Russell-Jones G, McTavish K, McEwan J, Rice J, Nowotnik D.
Vitamin-mediated targeting as a potential mechanism to increase
drug uptake by tumours. J. Inorg. Biochem. 2004;98(10):1625-1633.
31. Huang H, Long S, Li M, Gao F, Du J, Fan J, et al.Bromo-
pentamethine as mitochondria-targeted photosensitizers for cancer
cell apoptosis with high efficiency. Dyes Pigm. 2018;149:633-638.
32. Guicciardi ME, Leist M, Gores GJ. Lysosomes in cell death.
Oncogene. 2004;23(16):2881–2890.
33. Kroemer G, Jäättelä M. Lysosomes and autophagy in cell death
control. Nat. Rev. Cancer. 2005;5(11):886-895.
34. Bertram JS. The molecular biology of cancer. Mol. Aspects Med.
2000;21(6):167-223.
35. Dickerson M, Sun Y, Howerton B, Glazer EC. Modifying charge
and hydrophilicity of simple Ru (II) polypyridyl complexes radically
alters biological activities: old complexes, surprising new tricks.
Inorg. Chem. 2014;53(19):10370-10377.
36. Guicciardi ME, Leist M, Gores GJ. Lysosomes in cell death.
Oncogene. 2004;23:2881.
Reference
1.
2.
3.
4.
Siegel RL, Miller KD, Jemal A. Cancer Statistics Cancer J. Clin. .
2017;67(1):7-30.
Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, et
al.Cancer Statistics. Cancer J. Clin. . 2005;55(1):10-30.
Siegel R, Naishadham D, Jemal A. Cancer Statistics Cancer J. Clin. .
2013;63(1):11-30.
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M,
et al.Cancer incidence and mortality worldwide. Int. J. Cancer.
2015;136(5):359-386.
5.
6.
Dolmans DE, Fukumura D, Jain RK. Photodynamic therapy for
cancer. Nat. Rev. Cancer. 2003;3(5):380.
Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick
SO, et al.Photodynamic therapy of cancer: an update. Cancer J. Clin.
2011;61(4):250-281.
7.
Juarranz Á, Jaén P, Sanz-Rodríguez F, Cuevas J, González S.
Photodynamic therapy of cancer. Basic principles and applications.
Clin.Transl. Oncol. 2008;10(3):148-154.
8.
9.
Macdonald IJ, Dougherty TJ. Basic principles of photodynamic
therapy. J. Porphyr. Phthalocya. 2001;5(02):105-129.
Wilson BC, Patterson MS. The physics, biophysics and technology
of photodynamic therapy. Phys. Med. Biol. 2008;53(9):61-109.
10. Bian Y, Li M, Fan J, Du J, Long S, Peng X. A proton-activatable
aminated-chrysophanol sensitizer for photodynamic therapy. Dyes
Pigm. 2017;147:476-483.
11. Wang X-L, Wang H-W, Zhang L-L, Guo M-X, Huang Z. Topical
ALA photodynamic therapy for the treatment of severe acne
vulgaris. Photodiagnosis Photodyn. Ther. 2010;7(1):33-38.
12. Detty MR, Gibson SL, Wagner SJ. Current clinical and preclinical
photosensitizers for use in photodynamic therapy. J. Med. Chem.
2004;47(16):3897-3915.
13. Ormond A, Freeman H. Dye sensitizers for photodynamic therapy.
Materials. 2013;6(3):817-840.
14. Moreira LM, dos Santos FV, Lyon JP, Maftoum-Costa M, Pacheco-
Soares C, da Silva NS. Photodynamic therapy: porphyrins and
37. Kroemer G, Jäättelä M. Lysosomes and autophagy in cell death
control. Nature Reviews Cancer. 2005;5:886.
38. Lin CW, Shulok JR, Kirley SD, Bachelder CM, Flotte TJ, Sherwood
ME, et al.Photodynamic destruction of lysosomes mediated by Nile
blue photosensitizers. Photochem. Photobiol. . 1993;58(1):81-91.
39. Cincotta L, Foley JW, Cincotta AH. Phototoxicity, redox behavior,
and pharmacokinetics of benzophenoxazine analogues in EMT-6
murine sarcoma cells. Cancer Res. 1993;53(11):2571-2580.
40. Yao Q, Li H, Xian L, Xu F, Xia J, Fan J, et al.Differentiating RNA
from DNA by a molecular fluorescent probe based on the “door-
bolt” mechanism biomaterials. Biomaterials. 2018;177:78-87.
41. Zhao X, Li M, Sun W, Fan J, Du J, Peng X. An estrogen receptor
targeted ruthenium complex as a two-photon photodynamic therapy
agent for breast cancer cells. Chem. Commun. 2018;54(51):7038-
7041.
42. Foley JW, Song X, Demidova TN, Jilal F, Hamblin MR. Synthesis
and Properties of Benzo[a]phenoxazinium Chalcogen Analogues as
Novel Broad-Spectrum Antimicrobial Photosensitizers. J. Med.
Chem. . 2006;49(17):5291-5299.
43. Wolfgang Spiller HK, Dieter Wöhrle, Steffen Hackbarth, Beate
Röder, Günter Schnurpfeil. Singlet Oxygen Quantum Yields of
Different Photosensitizers in Polar Solvents and Micellar Solutions.
J. Porphyrins Phthalocyanines. 1998;02(02):145-158.
phthalocyanines
2008;61(10):741-754.
as
photosensitizers.
Aust.
J.
Chem.
15. Bugaj AM. Targeted photodynamic therapy--a promising strategy of
tumor treatment. Photochem. Photobiol. Sci. 2011;10(7):1097-1109.
16. Bio M, Rajaputra P, Nkepang G, Awuah SG, Hossion AM, You Y.
Site-specific and far-red-light-activatable prodrug of combretastatin
A-4 using photo-unclick chemistry. J. Med. Chem.
2013;56(10):3936-3942.
17. Copland JA, Eghtedari M, Popov VL, Kotov N, Mamedova N,
Motamedi M, et al.Bioconjugated gold nanoparticles as a molecular
based contrast agent: implications for imaging of deep tumors using
optoacoustic tomography. Mol. Imag. Biol. 2004;6(5):341-349.
18. Lukianova-Hleb EY, Oginsky AO, Samaniego AP, Shenefelt DL,
Wagner DS, Hafner JH, et al.Tunable plasmonic nanoprobes for
theranostics of prostate cancer. Theranostics. 2011;1:3.
44. Hu W, Ma H, Hou B, Zhao H, Ji Y, Jiang R, et al.Engineering
Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic
Imaging and Photodynamic Therapy under Near-Infrared Light.
ACS Appl. Mater. Interfaces. 2016;8(19):12039-12047.
45. Pena Luengas SL, Marin GH, Aviles K, Cruz Acuña R, Roque G,
Rodríguez Nieto F, et al.Enhanced singlet oxygen production by
photodynamic therapy and a novel method for its intracellular
measurement. Cancer Biother. Radio. 2014;29(10):435-443.
19. Mew D, Wat C-K, Towers G, Levy J. Photoimmunotherapy:
treatment of animal tumors with tumor-specific monoclonal
antibody-hematoporphyrin
1983;130(3):1473-1477.
20. Kim YH, Jeon J, Hong SH, Rhim WK, Lee YS, Youn H, et
al.Tumor targeting and imaging using cyclic RGD‐PEGylated gold
nanoparticle probes with directly conjugated iodine‐125. Small.
2011;7(14):2052-2060.
conjugates.
J.
Immunol.