10.1002/anie.202011140
Angewandte Chemie International Edition
COMMUNICATION
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Scheme 5. Conversion of the carboamination products into amino
acid derivatives.
In summary, we have developed a highly enantioselective
CpxCoIII-catalyzed intermolecular carboamination of alkenes. The
transformation is enabled by the tailored tri-substituted chiral Cpx
ligands. Two different alkene acceptors – acrylates and bicyclic
olefins provide access to attractive synthetic building blocks such
as non-natural isotyrosine derivatives and elaborated amino-
substituted bicycles. Strikingly, the chemoselectivity ‒ the product
range obtained ‒ is specific to cobalt catalysts, underscoring the
complementary behavior between cobalt and rhodium-based
catalytic systems. These findings will serve as a blueprint for
further developments of sustainable methodologies for the
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This work is supported by the Swiss National Science Foundation
(no 157741). This publication was created as part of NCCR
Catalysis, a National Centre of Competence in Research funded
by the Swiss National Science Foundation. S.O. is grateful for
support by Keio University Research Grant for Young
Researcher's Program and JSPS Grant-in-Aid for JSPS Fellows
Grant Number 19J13174. We thank Dr. R. Scopelliti and Dr. F.
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Keywords: Asymmetric Catalysis • Cobalt • C–H functionalization
• Carboamination • Chiral Cyclopentadienyl
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4
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