Acetamide, 2,2,2-trifluoro-N-phenoxy-

Base Information

• Chemical Name: Acetamide, 2,2,2-trifluoro-N-phenoxy-
• CAS No.: 96661-31-3
• Molecular Formula: C8H6F3NO2
• Molecular Weight: 205.136
• Mol file: 96661-31-3.mol

Synonyms:

Chemical Property of Acetamide, 2,2,2-trifluoro-N-phenoxy-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetamide, 2,2,2-trifluoro-N-phenoxy-

There total 1 articles about Acetamide, 2,2,2-trifluoro-N-phenoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylboronic acid (98-80-6) → 2,2,2-trifluoro-N-phenoxyacetamide (96661-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(II) acetate monohydrate; pyridine / 1,2-dichloro-ethane / Inert atmosphere; Molecular sieve

2.1: hydrazine hydrate / dichloromethane / Inert atmosphere

2.2: Inert atmosphere

With pyridine; copper(II) acetate monohydrate; hydrazine hydrate; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1002/anie.202011140

Reference yield: 49.0%

acrylic acid n-butyl ester (141-32-2,9003-49-0) + 2,2,2-trifluoro-N-phenoxyacetamide (96661-31-3) → (+)-butyl (S)-3-(2-hydroxyphenyl)-2-(2,2,2-trifluoroacetamido)propanoate

Guidance literature:

2,2,2-trifluoro-N-phenoxyacetamide; With C₃₃H₂₉CoI₂O₃; cesium acetate; silver trifluoromethanesulfonate; at 23 ℃; for 0.0166667h; Inert atmosphere; Glovebox; Molecular sieve; Sealed tube;

acrylic acid n-butyl ester; at 0 ℃; for 14h; enantioselective reaction; Inert atmosphere; Glovebox; Molecular sieve; Sealed tube;

DOI:10.1002/anie.202011140

Reference yield:

2,2,2-trifluoro-N-phenoxyacetamide (96661-31-3) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 4-Phenylphenol (92-69-3) + 2-Phenylphenol (90-43-7,287950-96-3)

Guidance literature:

trifluorormethanesulfonic acid; trifluoroacetic acid; for 2h; Product distribution; Ambient temperature;

DOI:10.1016/S0040-4020(01)91336-5

upstream raw materials:

phenylboronic acid

Downstream raw materials:

4-Phenylphenol

2-Phenylphenol

Refernces