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Chemical Science
DOI: 10.1039/C5SC01044F
Journal Name
RSCPublishing
ARTICLE
Figure 2. GC H2 detection for the dehydrogenation of cyclohexanone. The
gas sample was sampled from the reaction gas atmosphere (reaction
conditions: 1 mmol cyclohexanone, 5% mol Pd/C, 150 °C, 1.5 h, 2 ml DMA
under 1 atm N2 atmosphere). The H2 and N2 were confirmed by comparing
with standard H2 and N2 GC spectra.
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Dehydrogenation, excluding deprotonation, belongs to an
oxidation process. Therefore, to obtain efficient dehydroꢀ
genation processes, much attention was naturally turn to
developing effective catalysis with oxidants while largely
ignoring the advantages inherent in catalysis with a reducing
agent (H2). Our findings unlock opportunities for markedly
different synthetic strategies. These reactions achieve high
isolated yields, they are intrinsically devoid of complications
caused by overꢀoxidation in oxidative dehydrogenation, and the
catalyst tolerates useful substrates with diverse functional
groups, including aromatic, susceptible to oxidation and the
heteroatom substituents with strong coordinating ability. The
dehydrogenation do not need oxidants and hydrogen acceptors,
manifests the high atom economy. Moreover, the only byꢀ
product H2 of these reactions is a clean energy carrier.
Palladium on active carbon is an industrial commonly used and
recycled catalyst. Thus this Pd/C in combination with H2
catalytic dehydrogenation process displays considerable
promise for its practical application in an industrial setting.
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Acknowledgements
This work was financially supported by the National Natural
Science Foundation of China (grants 21072055) and the
Ministry of Science and Technology of China (grants
2008AA06Z306).
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Notes and references
Milstein Angew. Chem. Int. Ed. 2011, 50, 12240 i) B.
a School of Pharmacy, East China University of Science and Technology,
Meilong Road 130, Shanghai 200237, China. Eꢀmail: liurh@ecust.edu.cn;
Fax: 0086+21ꢀ64250627; Tel: 0086+21ꢀ64250627
Gnanaprakasam, D. Milstein J. Am. Chem. Soc. 2011, 133, 1682 j)
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† Electronic Supplementary Information (ESI) available: Experimental
procedures and 1H and 13C NMR of new materials. See
DOI: 10.1039/b000000x
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