The Journal of Organic Chemistry
Article
precharged with substrate and copper catalyst and then cooled with
dry ice or liquid nitrogen. With the dry ice as cooling bath, the amount
of liquid ammonia required was injected by a pressure syringe, and
then the vial was quickly sealed with a GC cap. After the required
amount of time, the vial was cooled with dry ice and the cap removed;
after the evaporation of ammonia, the products were collected and
analyzed by GC or HPLC. The structures of the products were
confirmed by GC−MS or LC−MS analysis. The amination of aryl
bromides and chlorides was conducted in several pressure tube rectors
as described above. The pressure tube reactor filled with liquid
ammonia solution was then placed in a GC oven to accurately control
the temperature of the reaction. The kinetics methods for the
amination of iodobenzene in liquid ammonia were similar to those
described previously.9
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AUTHOR INFORMATION
Corresponding Author
■
Notes
The authors declare no competing financial interest.
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