4. Conclusion
In summary, we have developed a simple and efficient multicomponent domino synthesis of indeno[1,2-b]quinoline derivatives using
the reaction of 1,3-indanedione, aryl-aldehyde, enaminone and p-toluene sulphonic acid (10 mol%) as an efficient catalyst at ambient
temperature using the grinding technique. The workup procedure is simple and excludes costly column chromatography procedure.
This method gives high yielding of pure products in short reaction time. The use of green, nontoxic, economical catalyst p- toluene
sulphonic acid has rendered this method eco-friendly.
Further, all the synthesized derivatives were evaluated for their anticonvulsant activity using the maximal electroshock (MES) method
using phenytoin as a standard drug along with their neurotoxicity effect. Derivatives 8b, 8e and 8k exhibited significant anticonvulsant
activity (P < 0.001). The neurotoxicity study clearly revealed that all the tested compounds are non-toxic at 40 mg/kg and so, new
compounds can be considered as good templates for further developmental studies and this study may lead to further investigations
aimed at discovering new drugs for the treatment of anticonvulsant disorders. The molecular modeling studies also predicted good
binding interactions of most active molecules with the serotonin 5-HT2A receptor (2VT4). Therefore, it can be safely concluded that
synthesized derivatives 8(a-n) would represent a useful model for further investigation in the development of a new class of
anticonvulsant agents.
Acknowledgment
We would like to thank the Director, TIT College of Pharmacy, Bhopal for providing research facilities. The authors are also grateful
1
to the Central Instrumentation Facility, IISER, Bhopal for HNMR spectral studies. The authors also gratefully acknowledge the
Sophisticated Analytical Instrumentation Laboratory (SAIL); SOPS, RGPV, Bhopal for Infrared and Mass spectral analysis of the
compounds used in this study.
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