Journal of Molecular Structure p. 349 - 356 (2019)
Update date:2022-08-11
Topics:
Guilherme, Fernanda Dias
Simonetti, Julia évelin
Folquitto, Lais Regina Santos
Reis, Adriana Cotta Cardoso
Oliver, Josidel Concei??o
Dias, Amanda Latércia Tranches
Dias, Danielle Ferreira
Carvalho, Diogo Teixeira
Brand?o, Geraldo Célio
Souza, Thiago Belarmino de
A new series of glycosylated acylhydrazones was synthesized and all the chemical structures were confirmed by High Resolution Mass Spectrometry (HRMS), 1H and 13C Nuclear Magnetic Resonance (1H-NMR; 13C-NMR) and Fourier Transform Infrared (FTIR) spectroscopy methods. The mass accuracy between the calculated and found values observed in HRMS analyses were near or lower than 5 ppm, which are acceptable for proposing a molecular formula using this technique. All of the synthesized compounds were screened for their antibacterial, antifungal and antiviral activities. Five compounds (12, 13, 14, 16 and 19) exerted a modest antifungal activity against the strains evaluated. Derivative 14 showed fungicidal activity against Candida glabrata at 173.8 μM and saccharide unit contributed to the increase of the antifungal potential against this strain. New chemical manipulation of derivative 14 can make it possible to obtain new potentially antimicrobial agents.
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