6
C. Liang et al.
4.1. General experimental procedure
A 50 ml round-bottomed flask was charged with α-methylene carbonyl compound 10 (5 mmol),
malononitrile 11 (5 mmol), and 25 ml H2O, which was stirred for 20 min under heating or ultra-
sound irradiation. Subsequently, sodium polysulfide 12 (5 mmol) was added and stirred at 70◦C
under conventional heating or ultrasound irradiation. The mixture became turbid at the end of the
reaction, which was poured into cold water. The crude product was isolated by filtration and was
further purified by recrystallization with ethanol to afford pure 2-aminothiophenes. All the prod-
ucts were isolated, and their isolated yields are given in Table 2. Identities of the products were
established by comparison of their physical and spectral data with those of reported compounds.
Acknowledgement
This work was supported by National Science and Technology Major Project of the Ministry of Science and Technology
of China (No. 2009ZX09301-006). We thank Dr Edward Clennan for his generous assistance in the preparation of this
manuscript. We appreciate the support from Center for Instrumental Analysis, China Pharmaceutical University, for their
contribution in the structural confirmation.
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