Molecules p. 8955 - 8967,13 (2012)
Update date:2022-08-11
Topics:
Ferreira, Hercules V.
Rocha, Lenilson C.
Severino, Richele P.
Porto, Andre L. M.
The lipase B from Candida antarctica (Novozym 435, CALB) efficiently catalyzed the kinetic resolution of some aliphatic secondary alcohols: (±)-4-methylpentan- 2-ol (1), (±)-5-methylhexan-2-ol (3), (±)-octan-2-ol (4), (±)-heptan-3-ol (5) and (±)-oct-1- en-3-ol (6). The lipase showed excellent enantioselectivities in the transesterifications of racemic aliphatic secondary alcohols producing the enantiopure alcohols (>99% ee) and acetates (>99% ee) with good yields. Kinetic resolution of rac-alcohols was successfully achieved with CALB lipase using simple conditions, vinyl acetate as acylating agent, and hexane as non-polar solvent.
View MoreBAODING SINO-CHEM INDUSTRY CO.,LTD
Contact:0312-5956088
Address:NO.8 FUXING ROAD,CHINA
Wuhan Soleado Technology Co.,Ltd.
Contact:86-2783341481 18971291927
Address:RM2405 Unit 1 Builing 1, Taiyin Tower, Changqing Road,Wuhan China
Hubei Lingsheng Pharmaceuticals Co., Ltd.
Contact:+86-0710-3538058
Address:Xiangyang City Xiangcheng Economic Development Zone, Hubei Province
jiangsu senxuan pharmaceutical and chemical co.,ltd
Contact:86-523-87982810
Address:hongqiao industrial zone,taixing,jiangsu china
ZHONGBEI NORTHLAND BIO-CHEM INDUSTRY CO.,LTD
Contact:+86-452-6055586
Address:5F, C Liandalijing Bulding,No 259 Xinjiang Road, Jianhua District
Doi:10.1016/0022-328X(85)87270-3
(1985)Doi:10.1055/s-2001-16070
(2001)Doi:10.1021/jm00104a008
(1992)Doi:10.1063/1.1744417
(1958)Doi:10.1039/c19680001272
(1968)Doi:10.1039/C8RA08338J
(2018)