BMP-2 INDUCTION OF COX-2
1439
4
. Rosen V, Cox K, Hattersley G 1996 Bone morphogenetic
proteins. In: Bilezikian JP, Raisz LG, Rodan GA (eds.) Prin-
ciples of Bone Biology. Academic Press, New York, NY,
USA, pp. 661–671.
. Yamaguchi A, Komori T, Suda T 2000 Regulation of osteo-
blast differentiation mediated by bone morphogenetic proteins,
hedgehogs, and Cbfa1. Endocr Rev 21:393–411.
Smad5 induces osteoblast-specific gene expression in the plu-
ripotent mesenchymal precursor cell line C2C12 Mol Cell Biol
20: 8783–8792.
20. Kujubu DA, Fletcher BS, Varnum BC, Lim RW, Herschman
HR 1991 TIS10, a phorbol ester tumor promoter-inducible
mRNA from Swiss 3T3 cells, encodes a novel prostaglandin
synthase/cyclooxygenase homologue. J Biol Chem 266:
12866–12872.
21. Fletcher BS, Kujubu DA, Perrin DM, Herschman HR 1992
Structure of the mitogen-inducible TIS10 gene and demonstra-
tion that the TIS10-encoded protein is a functional prostaglan-
din G/H synthase. J Biol Chem 267:4338–4344.
2. Bazan NG, Fletcher BS, Herschman HR, Mukherjee PK 1994
Platelet-activating factor and retinoic acid synergistically ac-
tivate the inducible prostaglandin synthase gene. Proc Natl
Acad Sci USA 91:5252–5256.
3. Morham SG, Langenbach R, Loftin CD, Tiano HF, Voulou-
manos N, Jennette JC, Mahler JF, Kluckman KD, Ledford A,
Lee CA 1995 Prostaglandin synthase 2 gene disruption causes
severe renal pathology in the mouse. Cell 83:473–482.
4. Okada Y, Lorenzo JA, Freeman AM, Tomita M, Morham SG,
Raisz LG, Pilbeam CC 2000 Prostaglandin G/H synthase-2 is
required for maximal formation of osteoclast-like cells in
culture J Clin Invest 105:823–832.
5
6
. Reddi AH 1994 Bone and cartilage differentiation. Curr Opin
Genet Dev 4:737–744.
7
. Kanatani M, Sugimoto T, Kaji H, Kobayashi T, Nishiyama K,
Fukase M, Kumegawa M, Chihara K 1995 Stimulatory effect
of bone morphogenetic protein-2 on osteoclast-like cell for-
mation and bone-resorbing activity. J Bone Miner Res 10:
2
2
2
2
1
681–1690.
8
9
. Koide M, Murase Y, Yamato K, Noguchi T, Okahashi N,
Nishihara T 1999 Bone morphogenetic protein-2 enhances
osteoclast formation mediated by interleukin-1alpha through
upregulation of osteoclast differentiation factor and
cyclooxygenase-2. Biochem Biophys Res Commun 259:97–
1
02.
. Abe E, Yamamoto M, Taguchi Y, Lecka-Czernik B, O’Brien
CA, Economides AN, Stahl N, Jilka RL, Manolagas SC 2000
Essential requirement of BMPs-2/4 for both osteoblast and
osteoclast formation in murine bone marrow cultures from
adult mice: Antagonism by noggin. J Bone Miner Res 15:663–
5. Pilbeam CC, Rao Y, Voznesensky O, Kawaguchi H, Alander
CB, Raisz LG, Herschman HR 1997 Transforming growth
factor-beta1 regulation of prostaglandin G/H synthase-2 ex-
pression in osteoblastic MC3T3–E1 cells. Endocrinology 138:
6
73.
1
0. Nishimura R, Kato Y, Chen D, Harris SE, Mundy GR, Yoneda
T 1998 Smad5 and DPC4 are key molecules in mediating
BMP-2-induced osteoblastic differentiation of the pluripotent
mesenchymal precursor cell line C2C12. J Biol Chem 273:
4
672–4682.
2
6. Okada Y, Voznesensky O, Herschman HR, Harrison JR, Pil-
beam CC 2000 Identification of multiple cis-acting elements
mediating the induction of prostaglandin G/H synthase-2 by
phorbol ester in murine osteoblastic cells. J Cell Biochem
1
872–1879.
1
1
1. Attisano L, Wrana JL 2000 Smads as transcriptional co-
modulators. Curr Opin Cell Biol 12:235–243.
2. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G 1997
Osf2/Cbfa1: A transcriptional activator of osteoblast differen-
tiation. Cell 89:747–754.
3. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K,
Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato
M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T 1997
Targeted disruption of Cbfa1 results in a complete lack of bone
formation owing to maturational arrest of osteoblasts. Cell
7
8:197–209.
2
2
2
7. Xie W, Herschman HR 1996 Transcriptional regulation of
prostaglandin synthase 2 gene expression by platelet-derived
growth factor and serum. J Biol Chem 271:31742–31748.
8. Raisz LG, Simmons HA 1985 Effects of parathyroid hormone
and cortisol on prostaglandin production by neonatal rat cal-
varia in vitro. Endocr Res 11:59–74.
9. Pilbeam CC, Fall PM, Alander CB, Raisz LG 1997 Differen-
tial effects of nonsteroidal anti-inflammatory drugs on consti-
tutive and inducible prostaglandin G/H synthase in cultured
bone cells. J Bone Miner Res 12:1198–1203.
0. Schinke T, Karsenty G 1999 Characterization of Osf1, an
osteoblast-specific transcription factor binding to a critical
cis-acting element in the mouse osteocalcin promoters. J Biol
Chem 274:30182–30189.
1. Kern B, Shen J, Starbuck M, Karsenty G 2001 Cbfa1 contrib-
utes to the osteoblast-specific expression of type I collagen
genes J Biol Chem 276:7101–7107.
2. Sato M, Morii E, Komori T, Kawahata H, Sugimoto M, Terai
K, Shimizu H, Yasui T, Ogihara H, Yasui N, Ochi T, Kitamura
Y, Ito Y, Nomura S 1998 Transcriptional regulation of os-
teopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in
the skeletal tissues. Oncogene 17:1517–1525.
3. Porte D, Tuckermann J, Becker M, Baumann B, Teurich S,
Higgins T, Owen MJ, Schorpp-Kistner M, Angel P 1999 Both
AP-1 and Cbfa1-like factors are required for the induction of
interstitial collagenase by parathyroid hormone. Oncogene 18:
667–678.
1
8
9:755–764.
1
1
1
4. Hoshi K, Komori T, Ozawa H 1999 Morphological character-
ization of skeletal cells in Cbfa1-deficient mice. Bone 25:639–
6
51.
3
5. Kobayashi H, Gao YH, Ueta C, Yamaguchi A, Komori T 2000
Multilineage differentiation of Cbfa1-deficient calvarial cells
in vitro. Biochem Biophys Res Commun 273:630–636.
6. Gao YH, Shinki T, Yuasa T, Kataoka-Enomoto H, Komori T,
Suda T, Yamaguchi A 1998 Potential role of cbfa1, an essen-
tial transcriptional factor for osteoblast differentiation, in os-
teoclastogenesis: Regulation of mRNA expression of oste-
oclast differentiation factor (ODF). Biochem Biophys Res
Commun 252:697–702.
7. Gori F, Thomas T, Hicok KC, Spelsberg TC, Riggs BL 1999
Differentiation of human marrow stromal precursor cells:
Bone morphogenetic protein-2 increases OSF2/CBFA1, en-
hances osteoblast commitment, and inhibits late adipocyte
maturation. J Bone Miner Res 14:1522–1535.
3
3
1
1
3
8. Chen D, Ji X, Harris MA, Feng JQ, Karsenty G, Celeste AJ,
Rosen V, Mundy GR, Harris SE 1998 Differential roles for
bone morphogenetic protein (BMP) receptor type IB and IA in
differentiation and specification of mesenchymal precursor 34. Selvamurugan N, Brown RJ, Partridge NC 2000 Regulation of
cells to osteoblast and adipocyte lineages. J Cell Biol 142:
collagenase-3 gene expression in osteoblastic and non-
osteoblastic cell lines. J Cell Biochem 79:182–190.
2
95–305.
1
9. Lee KS, Kim HJ, Li QL, Chi XZ, Ueta C, Komori T, Wozney 35. Jimenez MJ, Balbin M, Lopez JM, Alvarez J, Komori T,
JM, Kim EG, Choi JY, Ryoo HM, Bae SC 2000 Runx2 is a
common target of transforming growth factor beta 1 and bone
morphogenetic protein 2, and cooperation between Runx2 and
Lopez-Otin C 1999 Collagenase 3 is a target of Cbfa1, a
transcription factor of the runt gene family involved in bone
formation. Mol Cell Biol 19:4431–4442.