European Journal of Medicinal Chemistry (2019)
Update date:2022-08-10
Topics:
Abrunhosa-Thomas, Isabelle
Anizon, Fabrice
Artola, Alain
Dallel, Radhouane
Descheemaeker, Amélie
Giraud, Francis
Moreau, Pascale
Nauton, Lionel
Pinto-Pardo, Nicolas
Théry, Vincent
Visseq, Alexia
Mechanical Allodynia (MA), a frequent chronic pain symptom caused by innocuous stimuli, constitutes an unmet medical need, as treatments using analgesics available today are not always effective and can be associated with important side-effects. A series of 3,5-disubstituted pyridin-2(1H)-ones was designed, synthesized and evaluated in vivo toward a rat model of inflammatory MA. We found that the series rapidly and strongly prevented the development of MA. 3-(2-Bromophenyl)-5-(phenylamino)pyridin-2(1H)-one 69, the most active compound of the series, was also able to quickly reverse neuropathic MA in rats. Next, when 69 was evaluated toward a panel of 50 protein kinases (PK) in order to identify its potential biological target(s), we found that 69 is a p38α MAPK inhibitor, a PK known to contribute to pain hypersensitivity in animal models. 3,5-Disubstituted pyridin-2(1H)-ones thus could represent a novel class of analgesic for the treatment of MA.
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