Tetrahedron Letters p. 6537 - 6540 (1992)
Update date:2022-08-25
Topics:
Maggini, Michele
Prato, Maurizio
Ranelli, Massimo
Scorrano, Gianfranco
A total synthesis of (1S,2R,7S,8aR)-1,2,7-trihydroxyindolizidine 3 has been achieved in few steps from lactam 4. The dihydroxyderivative 14 has also been prepared with the same general synthetic approach adapting a Michael addition and a thioamide-diazoketone cyclocondensation as key steps.
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