10.1002/asia.201801324
Chemistry - An Asian Journal
COMMUNICATION
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experimental results that the Pd(II) carbene migratory insertion
process is favored over the competitive dicarbonylation.
In conclusion, we have reported a palladium-catalyzed four-
component cascade reaction involving carbonylation, Pd(II)
carbene migratory insertion and amination, affording -amino
ketones in a straightforward manner. This protocol exquisitely
combined metal carbene migratory insertion and two cascade
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processes in
a sequential manner. A series of control
experiments have revealed that the reaction follows a sequence
of carbonylation, acyl Pd(II) carbene formation, migratory
insertion and amination. The control experiments have also
shown that from the acyl Pd(II) species, carbene formation and
migratory insertion is favored over dicarbonylation. Finally, DFT
calculations provide insights into the detailed reaction
mechanism and rationalize the chemoselectivity observed for
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Acknowledgements
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This project is supported by the National Natural Science
Foundation of China (No. 21672256).
Keywords: carbene migratory insertion • multi-component
reaction • cascade reaction • DFT calculation • carbon monoxide
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