Tetrahedron Letters p. 2851 - 2854 (1981)
Update date:2022-08-17
Topics:
Tam, James P.
DiMarchi, Richard D.
Merrifield, R. B.
Peptides with C-terminal α-carboxamides were synthesized from a multi-detachable benzhydrylamine-resin containing a Boc-(4-acetoxy)benzhydrylamine handle of unambiguous origin.The peptides bound to the new resin are stable to trifluoroacetic acid, but are cleavable by hydrogen fluoride, base and nucleophiles to give unprotected or protected peptide fragments.
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