2-Amino-4-methylpentanamide

Base Information

• Chemical Name: 2-Amino-4-methylpentanamide
• CAS No.: 13079-20-4
• Deprecated CAS: 13366-40-0
• Molecular Formula: C6H14N2O
• Molecular Weight: 130.19
• European Community (EC) Number: 235-983-7
• DSSTox Substance ID: DTXSID70884571
• ChEMBL ID: CHEMBL296425
• Mol file: 13079-20-4.mol

Synonyms:2-Amino-4-methylpentanamide;13079-20-4;Pentanamide, 2-amino-4-methyl-;H-D-Leu-NH;EINECS 235-983-7;H-Leu-NH;H-Leu-NH HCl;leucinamide hydrochloride;leucinamid;2-Amino-4-methyl-pentanamide;SCHEMBL241527;CHEMBL296425;DTXSID70884571;(1)-2-Amino-4-methylvaleramide;(+-)-2-amino-4-methylvaleramide;BBL012271;STL163587;AKOS000176164;AKOS016051332;CS-0091401;FT-0744755;Pentanamide, 2-amino-4-methyl-, (.+.)-;Pentanamide, 2-amino-4-methyl-, (.+-.)-;D75125;EN300-862735

Chemical Property of 2-Amino-4-methylpentanamide

Chemical Property:

• Vapor Pressure: 0.0211mmHg at 25°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 130.110613074
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)CC(C(=O)N)N

Technology Process of 2-Amino-4-methylpentanamide

There total 36 articles about 2-Amino-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ H-L-Leu-NH2 (687-51-4,13079-20-4,13366-40-0,15893-47-7)

Guidance literature:

With p-cresol; hydrogen fluoride; at 0 ℃; for 1h;

DOI:10.1016/S0040-4039(01)81767-6

Reference yield: 72.0%

methyl (L)-leucinate hydrochloride (7517-19-3) → H-L-Leu-NH2 (687-51-4,13079-20-4,13366-40-0,15893-47-7)

Guidance literature:

With ammonium hydroxide;

DOI:10.1039/c9ob00884e

Reference yield:

Glycyl-L-leucine (869-19-2) + ammonium chloride + ammonia (7664-41-7) → H-L-Leu-NH2 (687-51-4,13079-20-4,13366-40-0,15893-47-7) + L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + glycine (56-40-6,18875-39-3,25718-94-9) + H-Gly-NH2 (598-41-4)

Guidance literature:

at 120 ℃;

DOI:10.1021/ja01611a036

upstream raw materials:

4-(2-methylpropyl)oxazolidine-2,5-dione

DL-leucine ethyl ester

(RS)-leucinonitrile

H-L-Leu-NH₂

Downstream raw materials:

Carbobenzoxy-S-benzyl-cysteinyl-leucinamid-(L,L)

Z-(β-O-Bz-Asp)-Leu-NH2

3-(2-methylpropyl)-6-phenyl-2(1H)-pyrazinone

3-(2-methylpropyl)-5-phenyl-2(1H)-pyrazinone

Refernces

• 1、 Rogozhin,S.V. et al.. "-". . . Retrieved 1971.
• 2、 Yang,Rising. "-". . p. 3183. Retrieved 1931.
• 3、 Otevrel, Jan,Svestka, David,Bobal, Pavel. "Bianthryl-based organocatalysts for the asymmetric Henry reaction of fluoroketones". supporting information. p. 5244 - 5248. Retrieved 2019/06/07.
• 4、 -. "3, 5-disubstituted hydantoin compound as well as preparation method and application thereof". Paragraph 0041; 0051; 0052; 0063; 0064. . Retrieved 2018/10/19.