Organic & Biomolecular Chemistry
Communication
gained substantial maturity compared to that of direct metal
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1
6e,f
insertion into the amide N–C bond.
We envision that enlist-
ing controlled sequential catalysis will enable the discovery of
new reactivity of amides by N–C bond cleavage. Investigations
directed at broadening the scope of the process and further
application of the nucleophilic reactivity platform of destabi-
lized amides are currently underway. However, within the
context of the classic electrophilic reactivity of carboxylic acid
derivatives, amide destabilization is sufficiently powerful to
overturn the reactivity preference of carbonyl functional groups. 11 (a) N. A. Weires, E. L. Baker and N. K. Garg, Nat. Chem.,
Y. L. thanks for a scholarship from the Priority Academic
Program Development of Jiangsu Higher Education-Yangzhou
University (BK2013016) and the National Natural Science
Foundation of China (21472161). Financial support for this
study was provided by Rutgers University. The Bruker 500 MHz
spectrometer used in this study was supported by an NSF-MRI
grant (CHE-1229030).
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