Ju Hyun Kim et al.
COMMUNICATIONS
Table 5. Reuse of Ru/C catalyst for synthesis of azoxyben-
Science and Technology (R11-2005-065). JHK thank the
Brain Korea 21 for fellowships.
ACHTUNGTRENNUNG
zene.[a]
Entry
Catalyst
Yield of 2a [%][b]
1
2
3
4
5
1st run
2nd run
3rd run
4th run
5th run
88 (10)
85 (9)
83 (10)
83 (9)
83 (9)
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Reactions were performed in a microwave tube equipped
with a stirring bar and capped with an aluminum cap. The
following were placed in the tube in order: 1 mmol of 1a,
3 equiv. of NaOH (0.12 g, 3 mmol), 4 mol% of catalyst
(25 mg of the immobilized Ru NPs on non-activated char-
coal), 0.3 mL of ethanol, 113 mL of n-dodecane (as an inter-
nal standard), and 2 mL of THF. The mixture was stirred at
608C for 18 h. The reaction mixture was extracted with
aqueous NH4Cl solution and ethyl acetate or dichlorome-
thane. The mixture was purified by flash chromatography on
silica gel (n-hexane/ethyl acetate=10:1) to afford 2.
Acknowledgements
This work was supported by a National Research Foundation
of Korea (NRF) grant funded by the Korea Government
(MEST) (2011-0031444) and the Basic Science Research Pro-
gram through the NRF funded by the Ministry of Education,
6
ꢂ 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Adv. Synth. Catal. 0000, 000, 0 – 0
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