Organic Letters
Letter
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was between the values of Ac-Pro-OMe (4.6) and Ac-Hyp-OMe
(6.1), although the melting temperature of CMP 5 is slightly
higher than that of CMP 4.35 CMP 12 completes the set of 3- and
4-hydroxylated collagens. The dihydroxylation approach de-
scribed here makes polyhydroxylated peptide natural products
accessible with less effort.
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ASSOCIATED CONTENT
* Supporting Information
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1942, 550, 99−133.
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The Supporting Information is available free of charge on the
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Experimental procedures for all reported compounds, 1H
and 13C spectra, HPLC chromatograms (PDF)
AUTHOR INFORMATION
Corresponding Author
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(27) Schumacher, K. K.; Jiang, J.; Joullie,
Asymmetry 1998, 9, 47−53.
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M. M. Tetrahedron:
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Drzewiecki, K. E.; Shreiber, D. I.; Nanda, V. Biochemistry 2015, 54,
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2822030.
ORCID
(29) Zhang, Y.; Malamakal, R. M.; Chenoweth, D. M. Angew. Chem.,
Int. Ed. 2015, 54, 10826−10832.
Notes
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The authors declare no competing financial interest.
(31) Melacini, G.; Feng, Y.; Goodman, M. J. Am. Chem. Soc. 1996, 118,
10725−10732.
ACKNOWLEDGMENTS
This work was supported by the LOEWE SynChemBio project,
funded by the German Federate State of Hesse.
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