(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

Base Information Edit

Chemical Name:(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
CAS No.:13726-69-7
Deprecated CAS:112770-75-9
Molecular Formula:C10H17NO5
Molecular Weight:231.249
Hs Code.:2933 99 80
European Community (EC) Number:604-011-7
UNII:RC99P5B8IG
Nikkaji Number:J725.643D
Wikidata:Q27288047
Mol file:13726-69-7.mol

Synonyms:13726-69-7;Boc-Hyp-OH;Boc-L-hydroxyproline;(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid;Boc-trans-4-hydroxy-L-proline;N-Boc-trans-4-hydroxy-L-proline;boc-hydroxyproline;(4r)-1-(tert-butoxycarbonyl)-4-hydroxy-l-proline;(2S,4R)-1-[(Tert-Butoxy)Carbonyl]-4-Hydroxypyrrolidine-2-Carboxylic Acid;N-Boc-(2S,4R)-4-hydroxyproline;UNII-RC99P5B8IG;boc-trans-hydroxy-l-proline;RC99P5B8IG;trans-N-Boc-4-hydroxy-L-proline;trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline;N-Boc-4-hydroxy-L-proline, trans-;(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid;NSC 343720;N-(tert-Butoxycarbonyl)hydroxy-L-proline;1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S,4R)-;trans-1-(tert-butoxycarbonyl)-4-hydroxy-l-proline;946610-68-0;(2S,4R)-1-tert-Butyl 4-hydroxy-1,2-pyrrolidinecarboxylate;MFCD00053370;Boc-L-trans-4-hydroxyproline;trans-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid;NSC-343720;1-(tert-Butoxycarbonyl)-4-hydroxyproline;n-boc-hydroxyproline;N-Boc-hydroxy proline;Boc-4(R)-hydroxyproline;N-BOC-L-hydroxy-proline;BOC trans-4-hydroxyproline;Boc-(2S,4R)-hydroxyproline;N-Boc trans-4-hydroxyproline;SCHEMBL116439;trans 4-hydroxy L-BOC-proline;(2S,4R)-N-Boc-4-hydroxyproline;(4R)-1-Boc-4-hydroxy-L-proline;CS-M3078;HY-I0781;STR07822;1-t-butoxycarbonyl-L-hydroxy-proline;AC-141;AKOS000277290;AKOS015836539;N-(tert-butoxycarbonyl)-hydroxyproline;N-tert-butoxycarbonyl-L-hydroxyproline;Boc-Hyp-OH, >=98.0% (TLC);N-tert-Butoxycarbonyl(4R)-hydroxyproline;TS-00615;N-tert-Butoxycarbonyl (4R)-hydroxyproline;AM20080277;EN300-35841;N-t-Butoxycarbonyl-trans-4-hydroxy-L-proline;trans-1-t-butoxycarbonyl-4-hydroxy-L-proline;M03213;n-tert-butoxycarbonyl-trans-4-hydroxy-l-proline;trans-4-hydroxy-n-tert-butoxycarbonyl-l-proline;(4R)-(tert-Butoxycarbonyl)-4-hydroxy-L-proline;N-tert-Butoxycarbonyl-(2S,4R)-4-hydroxyproline;AS-813/43496108;N-(TERT-BUTYLOXYCARBONYL)-4-HYDROXYPROLINE;N-BOC-4-HYDROXY-L-PROLINE, (4R)-(-)-;N-tert-Butyloxycarbonyl-trans-4-hydroxy-L-proline;(4R)-1-(tert-butoxy carbonyl)-4-hydroxy-L-proline;A1-00438;Boc-L-Hydroxyproline;Boc-trans-4-Hydroxy-L-proline;J-300152;Q-101690;(4R)-1-(tert-butyloxycarbonyl)-4-hydroxy-L-proline;Q27288047;Z330828112;(2S,4R)-1-t-butoxycarbonyl-2-carboxy-4-hydroxypyrrolidine;(2S, 4R)-1-t-Butoxycarbonyl-4-hydroxy-2-pyrrolidinecarboxylic acid;(2S,4R)-1-(tert-butoxycarbonyl)-2-carboxy-4-hydroxypyrrolidine;BOC-(2S,4R)-(-)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID;trans-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylicacid;(2S, 4R)-1-(t-butoxycarbonyl)-4-hydroxy-2-pyrrolidinecarboxylic acid;(2S, 4R)-1-(tert-butoxycarbonyl)-4-hydroxy-2-pyrrolidinecarboxylic acid;(2S,4R) 4-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester;(2S,4R)-1-(tert-butoxycarbonyl)-4-hydroxy-2-pyrrolidinecarboxylic acid;(2S,4R)-1-(tert-butoxycarbonyl)-4-hydroxy-pyrrolidine-2-carboxylic acid;(2S,4R)-4-hydroxy-1-(t-butoxycarbonyl)-2-pyrrolidinecarboxylic acid;(2S,4R)-4-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester;1-(t-butoxycarbonyl)-(2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid;(2S,4R)-4-HYDROXYPYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;1,2-PYRROLIDINEDICARBOXYLIC ACID, 4-HYDROXY-, 1-(1,1-DIMETHYLETHYL) ESTER, (2S-TRANS)-

Suppliers and Price of (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Boc-trans-4-Hydroxy-L-proline
25g
$ 408.00

TRC
Boc-trans-Hydroxy-L-proline
25g
$ 250.00

TRC
Boc-trans-Hydroxy-L-proline
5g
$ 110.00

TCI Chemical
trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline >98.0%(T)
5g
$ 18.00

SynQuest Laboratories
N-Boc-trans-4-hydroxy-L-proline 97%
25 g
$ 23.00

SynQuest Laboratories
N-Boc-trans-4-hydroxy-L-proline 97%
250 g
$ 104.00

SynQuest Laboratories
N-Boc-trans-4-hydroxy-L-proline 97%
100 g
$ 56.00

Sigma-Aldrich
Boc-Hyp-OH (cryst) Novabiochem?
25 g
$ 274.00

Sigma-Aldrich
Boc-Hyp-OH (cryst)
8530260025
$ 265.00

Sigma-Aldrich
Boc-Hyp-OH (cryst) Novabiochem?
100 g
$ 821.00

Total 178 raw suppliers

Chemical Property of (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid Edit

Chemical Property:

Vapor Pressure:9.99E-08mmHg at 25°C
Melting Point:123-127 °C(lit.)
Refractive Index:-68 ° (C=1, MeOH)
Boiling Point:390.9 °C at 760 mmHg
PKA:3.80±0.40(Predicted)
Flash Point:190.2 °C
PSA：87.07000
Density:1.312 g/cm³
LogP:0.37920
Storage Temp.:−20°C
Water Solubility.:very faint turbidity
XLogP3:0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:231.11067264
Heavy Atom Count:16
Complexity:296

Purity/Quality:

min 98.0% ^*data from raw suppliers

Boc-trans-4-Hydroxy-L-proline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC(CC1C(=O)O)O
Isomeric SMILES:CC(C)(C)OC(=O)N1C[C@@H](C[C@H]1C(=O)O)O
Uses boc-trans-Hydroxy-L-proline is used in the preparation of hydroxyproline derivatives. boc-trans-Hydroxy-L-proline is an intermediate in the synthesis of Fosinopril-d5 Sodium Salt (F727803), the labeled analogue of Fosinopril Sodium Salt (F727800), a phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.

Technology Process of (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

There total 30 articles about (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%