Technology Process of (2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid
There total 7 articles about (2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: hydrogen / Pd/CaCO3 / ethyl acetate
2: di-isopropyl azodicarboxylate, Ph3P / tetrahydrofuran / 12 h / -20 °C
3: hydrazine / ethanol / 6 h / Heating
4: Et3N / CH2Cl2
5: 78 percent / I2 / tetrahydrofuran; H2O / 6 h / 20 °C
6: Et3N / CH2Cl2
7: RuCl3*H2O, NaIO4, / CCl4; acetonitrile; H2O / 1 h / Ambient temperature
With
ruthenium trichloride; sodium periodate; di-isopropyl azodicarboxylate; hydrogen; iodine; triethylamine; triphenylphosphine; hydrazine;
Lindlar's catalyst;
In
tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1039/c39880001527
- Guidance literature:
-
With
ruthenium trichloride; sodium periodate;
In
tetrachloromethane; water; acetonitrile;
for 1h;
Ambient temperature;
DOI:10.1039/c39880001527
- Guidance literature:
-
Multi-step reaction with 6 steps
1: di-isopropyl azodicarboxylate, Ph3P / tetrahydrofuran / 12 h / -20 °C
2: hydrazine / ethanol / 6 h / Heating
3: Et3N / CH2Cl2
4: 78 percent / I2 / tetrahydrofuran; H2O / 6 h / 20 °C
5: Et3N / CH2Cl2
6: RuCl3*H2O, NaIO4, / CCl4; acetonitrile; H2O / 1 h / Ambient temperature
With
ruthenium trichloride; sodium periodate; di-isopropyl azodicarboxylate; iodine; triethylamine; triphenylphosphine; hydrazine;
In
tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1039/c39880001527