Tetrahedron Letters p. 4281 - 4282 (1996)
Update date:2022-08-17
Topics:
Harrowven, David C.
Poon, Hon Suen
When a solution of diethyl maleate and acetophenone is added to a cooled (-78°C) solution of a lithium amide the maleate derivative 3 is given in good yield. Pre-treatment of the lithium amide with TMSCl alters the course of this reaction dramatically. With half an equivalent of this additive the Michael adduct 4 is given in 62% yield while employing three equivalents leads to the silyl enol ether 5 in >85% yield.
View MoreHangzhou JINLAN Pharm-Drugs Technology Co., Ltd
website:http://www.jlpharms.com
Contact:+86-571-86982636
Address:Rm A606, Fuyi Center, jianqiao street, Jianggan Area
lianyungang jinkang pharmaceutical technology co., ltd.
Contact:008651885445517
Address:Jinshan industrial park, Ganyu county, Lianyungang, Jiangsu Province, 222115, China
Hunan Shineway Enterprise Co., Ltd.
Contact:+86-731-86303875
Address:118, Huanghua International Airport Road, Huanghua Town, Changsha, Hunan 410137, China
website:http://www.angchenchem.com
Contact:+86-510-88302099 82327577
Address:Rm. 404/405, Floor 4th, No. 983 FengXiang Road, Wuxi, China
Contact:USA:563-513-3839
Address:No.121TANGU EAST STREET,SHIJIAZHAUNG,CHINA
Doi:10.1002/anie.201907668
(2019)Doi:10.1021/ja4088743
(2013)Doi:10.1134/S0036024416020163
(2016)Doi:10.1021/jo00223a041
(1985)Doi:10.1002/adsc.200800632
(2009)Doi:10.1016/j.tet.2013.03.018
(2013)